%0 Journal Article %T ABC Transporters are Hub Genes in Response of Resistant E. Coli ST131 to Ciprofloxacin %A Alireza Ebadi Tabrizi %A Mojtaba Tahmoorespur %A Esmaeil Ebrahimie %J Archives of Pharmacy Practice %@ 2320-5210 %D 2021 %V 12 %N 3 %R 10.51847/QbEWIkOhCK %P 82-88 %X The worldwide spread of bacterial infection and the emergence of resistance to antibiotics have become two major problems in the field of medical sciences. As a serious threat, antibiotic resistance genes, in addition to pathogenic bacteria, have been found in bacteria that are generally recognized as safe. One of the common mechanisms of multidrug resistance (MDR) is due to overexpression of efflux pumps. ATP-binding cassette (ABC) transporters are one type of efflux pumps which have an important role in bacterial MDR. ABC transporters mediate the antibiotic expel from the bacterial cell by hydrolyzing ATP. In order to study antibiotic resistance caused by ABC transporters and to capture molecular/gene networks activated/inactivated by any antibiotic, a RNA-seq analysis is performed on Escherichia coli ST131 which is treated by ciprofloxacin. Based on gene expression analysis, 589 genes expressed differentially (FDR p-value %U https://archivepp.com/article/abc-transporters-are-hub-genes-in-response-of-resistant-e-coli-st131-to-ciprofloxacin-x5kpqt8dfjfwppg