Background: In Vietnam, the aging of the population was known as an important factor contributing to the increase in medical expenses, as medical expenses per capita were higher than in other age groups. Objectives: This analysis exhibited a theoretic model to evaluate the aging rate, quantitatively determining the consequences of aging on disease configurations and clarifying how these effects were attained. This study aimed to explore how the burden of diseases fluctuates conferring to the medical infrastructure level and variations in the aging index using WHO disease burden data and aging data. Methods: In this analysis, health data on the worldwide disease burden of elderly people was analyzed from 2016 to 2019. The difference model (DID) was applied to investigate the aging effects. Results: The burden of the disease increased over time, especially in the middle-aged population and the premature death in the people of middle and old age has augmented expressively. Studying the econometric model after checking the relevant factors showed a substantial rise in the number of fatalities due to premature death and illness. Contrary to this, the group of piles at the aging level had an imperative optimistic impact on the year life lost (YLL). As an important variable that shows the effect of a double age difference, the interaction effect did not affect the disability-adjusted year of life (DALY) but exhibited a substantial optimistic consequence on year life lost. Conclusion: Consequently, the effect of populace aging on future medical spending or medical resources should take into account the changes in the disease burden by age group, population structure and the interaction of these 2 incremental factors.