TY  - JOUR
T1  - Drivers of Multi-Drug Resistance to Anti-Tuberculosis Drugs in TB/HIV Co-Infection in Tuberculosis Patients
A1  - Yende Mupepe
A1  - Nsutier Kolnziam
A1  - Izana Pambi
A1  - Manyama Katata
A1  - Tene Masolo
A1  - Kiala Makola
A1  - Tukija Nkunda
A1  - Ikumunir Mutshil
A1  - Tshiama Claudine
A1  - Gédéon Bongo
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2025
VL  - 16
IS  - 2
DO  - 10.51847/NzhHwpLOLr
SP  - 19
EP  - 25
N2  - TB/HIV co-infection is a very heavy burden, and controlling or even eliminating it is a challenge for African countries and their health services. The leading cause of mortality for those with TB/HIV co-infection is still resistance to anti-tuberculosis medications, and the factors leading to it are little known because they are less documented. The main aim of this research was to determine the drivers of multi-drug resistance to anti-tuberculosis drugs in TB/HIV co-infection in tuberculosis patients in a hospital in Kinshasa. A descriptive cross-sectional study analyzed 25 records of patients with TB/HIV co-infection undergoing antiretroviral and anti-tuberculosis treatment at the Saint-Pierre de Kabambarré Hospital in Kinshasa. The mentioned files were analyzed over a period running from October 2023 to January 2024. A descriptive analysis revealed that environmental variables, including alcohol intake, had contributed to 46.6% of patients' development of resistance to anti-tuberculosis medications, loss of sight due to relocation, compared with 40% as a result of economic factors, in particular poverty and geographical inaccessibility. Only 32% of resistance was linked to medical factors: stock-outs of anti-tuberculosis drugs, and 41% of respondents developed resistance as a result of biological factors. On the other hand, only 12% of patients developed resistant relapses due to socio-demographic factors, such as discrimination and the myth surrounding tuberculosis. Poverty combined with the global economic collapse, geographical inaccessibility, stock-outs of anti-tuberculosis drugs and antiretrovirals, increased viral load, discrimination and the myth surrounding tuberculosis are responsible for anti-tuberculosis drug resistance in patients with HIV/TB co-infection. 
UR  - https://archivepp.com/article/drivers-of-multi-drug-resistance-to-anti-tuberculosis-drugs-in-tbhiv-co-infection-in-tuberculosis-p-ryykkovrboo7tpu
ER  -