TY - JOUR T1 - Epilepsy in Patients with Craniosynostosis: A Systematic Review A1 - Abdulkarim Muhanna Alanazi A1 - Sarah Khudayer Alabdullatif A1 - Abdulaziz Saeed Alghamdi A1 - Amirh Ayman Zamzami A1 - Laura Almazyad A1 - Amjad Mohammed Alakel A1 - Mohammed Ali Ahmad Alzahrani A1 - Layan Tariq Almazyad A1 - Rahaf Hussein AlRuwaili A1 - Mahdi Ibrahim Ahmad Almuhaysin JF - Archives of Pharmacy Practice JO - Arch Pharm Pract SN - 2320-5210 Y1 - 2022 VL - 13 IS - 4 DO - 10.51847/negpA51WKN SP - 24 EP - 29 N2 - If left untreated, craniosynostosis can cause neuropsychological impairments, psychosocial problems, and craniofacial deformities. Its association with epileptic seizures is unknown. This review investigated the incidence of epilepsy in patients with craniosynostosis. The Cochrane Library, Science Direct, Web of Science, EBSCO, and PubMed were all searched. Rayyan QCRI was used to filter study article titles and abstracts before full-text evaluations were conducted. In total, 11 studies involving 21456 patients with craniosynostosis were examined; more than half of the patients were men. The highest reported rate of preoperative epileptic seizures was 12.2%, and the lowest rate was 2.5%. The highest rate of post-operative epilepsy was 12.2%, and the lowest was 0.24%. There is a lack of literature on epileptic seizures as an outcome among craniosynostosis patients. The metabolic or hemodynamic events following craniosynostosis corrective surgeries were more significant. However, neurological manifestations, including epilepsy, require close monitoring. We found that syndromic craniosynostosis patients experienced more significant problems than non-syndromic patients. UR - https://archivepp.com/article/epilepsy-in-patients-with-craniosynostosis-a-systematic-review-ey1pspo0tl0opdv ER -