TY  - JOUR
T1  - Estimation of Equivalence for Quality Parameters of Metoclopramide Hydrochloride Tablets Used to Treat Emesis
A1  - Zeb-un-Nisa Zeb-un-Nisa
A1  - Saira Shahnaz
A1  - Mehwish Rizvi
A1  - Rasheeda Fatima
A1  - Saba Inayat Ali
A1  - Shumaila Shafique
A1  - Hina Saleem
A1  - Tayyaba Faraz
A1  - Mehwish Murad Ali
A1  - Muhammad Mustafa Swaleh
A1  - Nida Ghani
A1  - Syed Sammar Abbas
A1  - Faiza Khan
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2021
VL  - 12
IS  - 2
DO  - 10.51847/xuwqnWXsOY
SP  - 25
EP  - 28
N2  - Metoclopramide hydrochloride is used for the treatment of emesis. It is also used for chemotherapy and radiotherapy, and migraine induced nausea and vomiting. The objective of the study was the comparative assessment of different brands of metoclopramide hydrochloride. Different physiochemical tests according to USP were performed using different instruments. Scanning electron microscopy was also performed.  Methanol, (Merck, Darmstadt, Germany) was used as regents. A reported method was utilized for the assay and dissolution studies.  The results in weight variation test and friability ed within the pharmacopeia specified limits.  The strength of the branded tablets was 6.15±0.18 to 8.77±0.38 kg. The disintegration time was within 4.1±0.52 to 7.11± 0.39 min. FT-IR and SEM analysis depicted complete compatibility between the active and excipients. The assay and dissolution results showed determination at 272 and 309 nm with USP limits. The spectrophotometric methods assess the quality and efficacy of tablets effectively, hence the evaluation provides the evidence to choose the brands for treatment. 
UR  - https://archivepp.com/article/estimation-of-equivalence-for-quality-parameters-of-metoclopramide-hydrochloride-tablets-used-to-tre-jitj8kstrj2ms5o
ER  -