TY  - JOUR
T1  - Evaluation of Hemochromatosis, Diagnosis and Management: Simple Literature Review
A1  - Abdulmalek Adel Aboulkhair
A1  - Abdulrahman Ibn Almuataz Ezzi
A1  - Tariek Abdullah Alharbi
A1  - Ali Sultan Alzughbi
A1  - Khalid Melih Marick Alshammari
A1  - Sultan Musallam Alshammari
A1  - Mansour Thallab Albagami
A1  - Kawther Abdulla Alsadady
A1  - Thamer Hamad M Alshahrani
A1  - Fatheya Ahmed Hussain
A1  - Anwar M. Al Hadhari
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2020
VL  - 11
IS  - 3
SP  - 101
EP  - 103
N2  - Background: Hemochromatosis is an autosomal recessive genetic disorder characterized by abnormal iron regulation in the body leading to excessive iron deposition in multiple organs. Most of the patients of hemochromatosis are presymptomatic or asymptomatic. Nevertheless, a minority of patients presents with severe complications. Objective: In this study, we aimed to discuss the published literature focused on diagnosing and managing hemochromatosis. Method: PubMed database was used for articles selection, and the following keys were used in the mesh ((“hemochromatosis”[Mesh]) and (“hemochromatosis management”[Mesh])). The articles' selection was based on the relevance to the topic as their primary endpoint. Conclusion: The stage of the disease and particularly the extent of iron overloading should be the parameters that are dependent on assessment and treatment. Phlebotomy is the mainstay of treatment in hemochromatosis cases. It improves insulin sensitivity, fatigue, and skin pigmentation. Initiating the phlebotomy before the development of liver cirrhosis has shown a significant decrease in morbidity and mortality rates. Iron chelation therapy can be an option when the hemoglobin of the patients cannot tolerate therapeutic phlebotomy.
UR  - https://archivepp.com/article/evaluation-of-hemochromatosis-diagnosis-and-management-simple-literature-review
ER  -