%0 Journal Article
%T Glucomannan Ameliorates Hepatic Lipid Metabolism and Glucose Homeostasis in Rat Models Fed a High-Fat Diet
%A Roaa M. Alreemi
%A Khadija S. Radhi
%A Taqwa Bushnaq
%A Ohud Saleh
%A Reem S. Alazragi
%J Archives of Pharmacy Practice
%@ 2320-5210
%D 2024
%V 15
%N 1
%R 10.51847/IUaZmNExfl
%P 121-126
%X This work was conducted to investigate the effects of glucomannan extracted from konjac (KGM) on high-fat diet (HFD)-)-induced lipid metabolic abnormalities and dysglycaemia and explore its possible mechanisms. Sixty adult male albino rats (Sprague-Dawley) were separated into five groups: G1 (control) fed a basal fat diet (BFD); G2, fed a high-fat modified diet containing 20% fat (HFD); and G3, G4, and G5, fed an HFD supplemented with three levels of KGM (1, 5, and 10 g/100 g diet, respectively). Results showed that rats fed HFDs developed hepatic glucose and lipid abnormalities. Glucomannan administration normalized hepatic glucose metabolism in HFD-fed rats with low fasting blood glucose. KGM may postpone obesity, diabetes, and associated consequences as a dietary intervention.  To sum up, supplementing rats with 10 g/100g dietary Glucomannan improves blood lipid levels, lipid metabolism in the liver, and glucose regulation. This suggests that KGM could be supplied in the future as a potential anti-hyperglycaemic and antilipidemic dietary supplement. 
%U https://archivepp.com/article/glucomannan-ameliorates-hepatic-lipid-metabolism-and-glucose-homeostasis-in-rat-models-fed-a-high-fa-wegwijeucjjdghu