%0 Journal Article
%T Metafiltrate-Based Dietary Supplement to Improve Gut Biocenosis and Support Metabolic Detoxification
%A Maria Anatolevna Zakharenko
%A Valeriy Mikhailovich Poznyakovsky
%A Lapina Valentina
%A Ulubieva Elena Arsenovna
%A Kulova Laura Alexandrovna
%A Loseva Anna Ivanovna
%J Archives of Pharmacy Practice
%@ 2320-5210
%D 2023
%V 14
%N 4
%R 10.51847/ibxuWKpGAv
%P 131-137
%X The present study deals with a new highly effective functional product, a dietary supplement, to improve gut biocenosis and support metabolic detoxification. The supplement includes the following ingredients (mg per capsule): postbiotic metafiltrate -200; natural zeolite -130.36; polysorbovit – 105 (soluble dietary fiber – 100); silicon dioxide – 14.46; lipase – 10; bromelain – 10; papain – 10; cellulase – 10; rutin – 6; chitosan – 5; lysozyme hydrochloride – 5. The supplement is considered innovative as capsules have a special enteric coating to provide successive and targeted delivery of ingredients to the gastrointestinal tract cells while preserving safety and bioactivity. The antimicrobial and antifungal activity of the postbiotic metafiltrate has been studied. The mechanism of endotoxin neutralization and biocenosis normalization is characterized by the following factors: the destruction of toxic peptidoglycans of the bacterial cell wall and proteins and peptides with different chain lengths; elimination of Candida albicans cells by destroying bonds in the beta-glycan molecule of the fungal cell wall; cleavage of toxic lipid A of lipopolysaccharides; the influence of the culture fluid metabolites of probiotic microorganisms; high sorption capacity and selectivity for endotoxins, toxic metabolites, pathogenic microorganisms, free radicals, allergens, and antigens. The product has been included in the volunteers’ diet and its efficacy has been assessed. The product's role in metabolic detoxification and biocenosis normalization has been studied. The recommended dosage is 1 capsule twice a day with a meal for 30 days. 
%U https://archivepp.com/article/metafiltrate-based-dietary-supplement-to-improve-gut-biocenosis-and-support-metabolic-detoxification-reutenhvlz8whpg