TY  - JOUR
T1  - Preparation and In-Vitro Evaluation of Sustained Release Matrix Diclofenac Sodium Tablets Using HPMC KM 100  and Gums
A1  - Zafar Iqball
A1  - Raza Khan
A1  - Fazli Nasir
A1  - Jamshaid Ali Khan
A1  - Lateef Ahmadl
A1  - Abad Khan
A1  - Yaser Shah
A1  - Abdullah  Dayo
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2010
VL  - 1
IS  - 2
SP  - 9
EP  - 13
N2  - Objectives: The impact of hydroxypropylmethyl cellulose (HPMC K 100M) alone and in combination with the guar gum, xanthan gum and gum tragacanth on the release of the diclofenac sodium matrix tablets were evaluated.

Materials and Methods: The granules were prepared using wet granulation method and compressed into tablets using different ratio of drug and gum ratio. The physical properties of the tablets were within acceptable pharmacopeial limits. The release profiles of the matrix tablets were evaluated in-vitro, using USP dissolution apparatus II (paddle method). Results: The formulations containing HPMC K 100M drug ratio 1:1.3 and 1:1.6 and formulations containing HPMC, gum and drug with different ratio also sustained the release of diclofenac sodium for 12 hours. The mechanism of drug release from the matrix tablets was studied using Zero order, First order, Higuchi and Korsmeyer's models using regression coefficient method. The stability of the selected formulations was evaluated at 40°C and 70% RH for 6 months.

Conclusions: HPMC K100M alone and in combination with natural gums as the retarding material retarded the release up to 12 hours and showed little deviation from the theoretical release pattern.
UR  - https://archivepp.com/article/preparation-and-in-vitro-evaluation-of-sustained-release-matrix-diclofenac-sodium-tablets-using-hpmc-km-100-and-gums
ER  -