TY  - JOUR
T1  - Q-myocardial Infarction on the Background of Undifferentiated Connective Tissue Dysplasia: Pathogenetic “Paradoxes” and “Crossovers”
A1  - Mariia Chernykh
A1  - Olena Solyeyko
A1  - Larysa Soleyko
A1  - Yevhenii Mironov
A1  - Olena Terekhovska
A1  - Arthur Berezovskiy
A1  - Oleg Fedorchenko
A1  - Lena Davtian
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2022
VL  - 13
IS  - 4
DO  - 10.51847/hdCqPRLP8u
SP  - 40
EP  - 44
N2  - Acute myocardial infarction (MI) is an important public health problem. Modern cardiology studies the role of such a premorbid background as undifferentiated connective tissue dysplasia (UCTD) in the pathogenesis of coronary heart disease (CHD) and MI in particular. Despite a large number of studies, the biochemical pathogenetic links of MI development against the background of UCTD remain unexplored. That is why our study aimed to analyze the stigmas of dysembryogenesis, coagulogram parameters, and platelet and uric acid (UA) levels as the most expected factors in the pathogenesis of MI with UCTD. The level of platelets in the peripheral blood of patients with UCTD (182.0 [161.0–265.0] x 109/l) did not differ reliably (but it was still significantly lower) from that in patients without UCTD [230.0 [206.0–309.0] x 109/l) (p>0.05). In particular, in 26 patients (57.8%) with UCTD, it was below the reference value. In those patients, who also have a large number of UCTD markers (10 or more), the stigma of “easy hematoma formation with insignificant damage” was most common. The level of UA in patients with Q-IM with UCTD was higher than normal and reliably higher than in the group without dysplasia (383.60 ± 33.82 vs. 292.11 ± 28.56, p
UR  - https://archivepp.com/article/q-myocardial-infarction-on-the-background-of-undifferentiated-connective-tissue-dysplasia-pathogene-uvxnklgfrxuxlfr
ER  -