TY  - JOUR
T1  - RP-HPLC Method for Dapagliflozin and Metformin HCL in Bulk and Combined Formulation
A1  - Khagga Bhavyasri
A1  - Thaneeru Surekha
A1  - Samreen Begum
A1  - Mogili Sumakanth
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2021
VL  - 12
IS  - 4
DO  - 10.51847/Czxl0wYrYr
SP  - 106
EP  - 110
N2  - The given RP-HPLC technique was found to be clear-cut, specific, exact, and economical for estimation of Dapagliflozin and Metformin HCl in bulk and tablet dosage form. Stationary phase Phenomenex C18 250mm x 4.6 mm were utilized as chromatographic conditions. Water: Methanol in the ratio of 50:50 was used as fluid phase. The flow rate was maintained at 5 1.0ml/min, wave length of detection was 230 nm and diluent was water all maintained at a 300C column temperature. As an optimized procedure, the conditions were finalized. By injecting the standard six times, apt system factors were studied and the outcomes were considerably below the acceptance criteria. Metformin HCl linearity was found to be 2-7 ppm and Dapagliflozin linearity was found to be 60-210 ppm with r2=0.999. For Dapagliflozin and Metformin HCl, precision value was found to be 0.8214% and 0.6342% respectively. For Dapagliflozin, LOD and LOQ values were found to be 345000 ppb and 415000 ppb respectively and for Metformin HCl LOD and LOQ values were found to be 263000 and 324000 ppb respectively. Assessment of the formulated market was carried out by using above method and percentage of Dapagliflozin and Metformin HCl was found to be 99.73 % and 99.85 % respectively. 
UR  - https://archivepp.com/article/rp-hplc-method-for-dapagliflozin-and-metformin-hcl-in-bulk-and-combined-formulation-rhgl5ee5wa4xvhz
ER  -