TY  - JOUR
T1  - Study on the Effect of Ethanol Ginger Extract on Cell Viability And p53 Level in Breast and Pancreatic Cancer
A1  - Soroush Sarami
A1  - Maryam Dadmanesh
A1  - Zuhair M. Hassan
A1  - Khodayar Ghorban
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2020
VL  - 11
IS  - 3
SP  - 115
EP  - 121
N2  - Cancer is a widespread disease in which regulatory mechanisms of cell growth and proliferation has led into failure and results in continuous cell reproduction. Today, breast and pancreatic cancers are two common and lethal diseases. In recent years anti-cancer effects of natural products like Ginger and its bioactive compounds has taken into consideration. In this study effect of ginger treatment was evaluated on viability and the p53 level of Panc-1 and MCF-7 Cell line. At first Cancerous and normal cells were cultured and then treated with different concentrations of ethanol ginger extract for 24 and 48 hours and eventually MTT assay was conducted to investigate the cytotoxic effect. Then we tested the p53 level in all three cells. In MTT assay we observed that ginger extract kills cancerous cell line in a dose-dependent pattern with IC50 of 40.8 and 61.5 µg/ml for MCF-7 and Panc-1 respectively, while no significant cytotoxic effect was observed on normal cells. P53 level was significantly increased in MCF-7 and Panc-1 and not in PBMCs (P
UR  - https://archivepp.com/article/study-on-the-effect-of-ethanol-ginger-extract-on-cell-viability-and-p53-level-in-breast-and-pancreatic-cancer
ER  -