TY  - JOUR
T1  - The Effect of Premedication Dexamethasone on Exacerbation of Acute Hypoxic Brain Injury in Adult Mice
A1  - Shayeste Khorasanizadeh
A1  - Faranak Behnaz
A1  - Hamidreza Azizi Faresani
A1  - Masih Ebrahimy Dehkordy
A1  - Homeyra Kouzekanani
A1  - Afshin Moradi
A1  - Seyyed Masoud Hashemi
A1  - Gholamreza Mohseni
A1  - Houman Teymourian
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2019
VL  - 10
IS  - 3
SP  - 112
EP  - 118
N2  - Premedication as an important component of pre-anesthetic drugs can be either very useful or dangerous and may disrupt the outcome of a surgery. For example, premedication dexamethasone may change normal body responses to stressors such as acute hypoxia through various mechanisms, such as inhibiting the pituitary-hypothalamic axis. Using nonselective nitric oxide synthase inhibitors (10mg/kg L-Name) and a selective neuronal blocker (40mg/kg NOS 7-NI), this study did not prevent the negative effects of dexamethasone as a premedication.  Concomitant injection of dexamethasone 0.2 mg/kg as a pretreatment, a NO precursor blocker (L-arginine 60mg/kg) and an NMDA receptor blocker (0.5mg/kg Ketamine) 30 minutes before acute hypoxia also could not be a stimulus for adult mice normal responses to hypoxia. The results of this study showed that injection of premedication dexamethasone at a dose of 0.2mg/kg or higher three days before surgery decreased the response to acute hypoxia and disrupted Tail Test 60 minutes after hypoxia in the adult mouse completely and its effect remained for several hours.
UR  - https://archivepp.com/article/the-effect-of-premedication-dexamethasone-on-exacerbation-of-acute-hypoxic-brain-injury-in-adult-mice
ER  -