TY  - JOUR
T1  - Toxicity of Substance BKP-115 on Rats and Mice of Both Sexes at Long Term Intragastric Introduction
A1  - Oleksii Bigdan
JF  - Archives of Pharmacy Practice
JO  - Arch Pharm Pract
SN  - 2320-5210
Y1  - 2021
VL  - 12
IS  - 2
DO  - 10.51847/v8MvJ5IqGt
SP  - 6
EP  - 11
N2  - Today there is a large number of scientific publications in which the heterocyclic systems of 1,2,4-triazole and their derivatives are studied. Many of the medications, which contain compounds with the 1,2,4-triazole ring, were discovered and applied in practice. For many years, 1,2,4-triazole derivatives remain the object of close attention of scientists of various scientific fields. The unique properties of 1,2,4-triazole derivatives include high reactivity, which allows different modification of this system, practical absence of toxicity of these derivatives, and the presence of a wide range of biological and pharmacological properties. 

For our research, we find the most promising compound for the study of acute toxicity. There is BKP-115, which shows interesting results in the classification of substances for toxicity class IV-V. The purpose of the work is to study the toxicity of substance BKP-115 on rats and mice of both sexes at long-term intragastric introduction, macroscopic examination of internal organs, and histostructure of internal organs. 
UR  - https://archivepp.com/article/toxicity-of-substance-bkp-115-on-rats-and-mice-of-both-sexes-at-long-term-intragastric-introduction-nzrvecao418gqz8
ER  -