Telemedicine has been increasingly used in the provision of health care services to older adults. The objective of this study was to investigate the impact of telemedicine use on clinical and self-reported outcomes of older patients through systematic review and meta-analysis. Online search was made from PubMed, psycINFO, Scopus, Ovid (Embase, Emcare), and EBSCOhost for randomized controlled trials and quasi-experimental studies evaluating the effect of telemedicine on clinical and self-reported outcomes of older patients (age>60 years). A total of seven studies were included in this review. Among the clinical outcomes, telemedicine had a statistically significant effect on systolic blood pressure (-3.83; 95% CI [-6.04, -1.61]; I2=77%;p=0.001) and glycosylated hemoglobin (-0.20; 95% CI [-0.35, -0.04]; I2=0; p=0.01). Whereas, no significant effect was observed for diastolic blood pressure (-0.92;95%CI [-2.14,0.30]; I2 0%; p=0.44), low-density lipoprotein (-0.01; 95%CI [-0.09,0.07]; I2=0%;p=0.930), and body weight (0.15;95%CI [-0.74,1.05]; I2 =0%;p=0.420. Depressive symptoms rating was assessed using two different measurement tools, Geriatric Depression Scale (GDS) and Patient Health Questionnaire 9 (PHQ-9). Significant effect was reported with PHQ-9 (-3.11;95%CI [-4.68,-1.55];I2=93%;p=0.0002). Results from this systematic review suggest that key clinical outcomes and health behavior of older patients can be improved using telemedicine.