Herbs and plant products have long been utilized for the treatment, prevention, and promotion of health. Despite the awareness of potential risks associated with herbs, such as interactions with medications and inaccurate dosing, many individuals continue to use them without seeking medical consultation. This study aims to determine the prevalence of herbal self-remedies among Saudi Arabian adults and evaluate their knowledge and attitudes toward herbal medicines. A cross-sectional study. The study was include adult participants aged 18 years and above, residing in Saudi Arabia. Individuals below 18 years of age and non-residents were excluded. The minimum required sample size is 377, with a confidence level of 95%. Data analysis was performed using SPSS software. Natural herbs are the most commonly used complementary and alternative treatment at 38.6%. The purpose of using herbal medicine varies among respondents, with 46.5% citing therapeutic purposes, 30.6% citing preventive purposes, and 14.1% citing cosmetic purposes. When it comes to knowledge about herbal medicine, the survey found that 38.7% of respondents rated their knowledge as weak, while 46.6% rated their knowledge as moderate. Only 11.9% of respondents rated their knowledge as very good when it comes to possible interactions between herbs and drugs. While there is a good understanding of the benefits and risks associated with herbal remedies, there are still gaps in knowledge and attitudes that need to be addressed.