This study aimed to investigate the impact of concentrated topinambur extract (CTE) on low-density lipoprotein cholesterol (LDLC) and high-density lipoprotein cholesterol (HDLC) levels in individuals suffering from atherogenic dyslipidemia. The control group adhered to a standard low-calorie diet throughout the treatment period. Meanwhile, the main group followed a modified version of the same diet, incorporating 100 mL of CTE. Our research into the use of CTE in treating dyslipidemia yielded valuable data. The findings indicate that this treatment option is well-tolerated and comparable to standard diet therapy in terms of weight loss. Moreover, we observed a positive impact on blood lipid profile. There was a statistically significant reduction in LDLC levels, while HDLC remained unchanged. This suggests a targeted effect on cholesterol levels without compromising overall cardiovascular health. Furthermore, there were no changes in liver function markers such as aspartate transaminase (AST), alanine aminotransferase (ALT), creatinine, or uric acid among patients receiving CTE.