This study aimed to evaluate the results of "hybrid operations" in patients with multilevel lesions of the lower extremities. For this study, 26 patients who underwent "hybrid operations" from 2023 to 2024 were selected. Ultrasound Dopplerography, ultrasound duplex scanning, and CT angiography were used to study the main arteries of the lower extremities. All patients were divided into two groups. In the first group, the ilio-femoral segment underwent isolated open reconstruction. In the second group hybrid revascularization of the same segment was performed with multilevel lesions of the arteries of the lower extremities. It was found that performing open methods of revascularization of the distal bed is possible only in the presence of adequate outflow through the arteries of the lower leg, which has the advantage of hybrid operations. The traumatism of hybrid operations is less, which is better tolerated by patients with severe concomitant diseases. Notably, hybrid revascularization operations are the method of choice in patients with chronic lower limb ischemia of the IV degree, contributing to faster healing of trophic disorders and preservation of the limb for a longer period.