Arch Pharm Pract archivepp.com Arch Pharm Pract Archives of Pharmacy Practice 2320-5210 archivepp.com-1198 10.51847/Nu1RwJxUns Case report High Levels of Blood Lactate Associated with the Use of Low Dose Aspirin: A Case-Control Study Bona Carina 1 Lozano Roberto 2 Unit for the Rational Use of Medicines, Aragon Health Service, Zaragoza, Spain. Departament of Pharmacy, University Clinical Hospital “Lozano Blesa”, Zaragoza, Spain. Address for correspondence: Prof. Wael Abu Dayyih, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan. E-mail: rlozano@salud.aragon.es 18 07 2024 15 3 10 12 Copyright: © 2026 Archives of Pharmacy Practice 2026 https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. A<sc>BSTRACT</sc>

We evaluate the risk of severe hyperlactatemia (LA) >4 in patients on chronic treatment with low doses of aspirin (ASP) and estimate the magnitude of the association. For this, a case-crossover study design, where patients who have experienced the outcome (cases) are a part of their controls by containing a period before the onset of the outcome. Additionally, a design based on person-day measurements, rather than individuals, was used for cases and controls. When comparing the group of cases (exposed to ASP/not exposed), we found: 127/578 vs. group controls (ASP exposed/unexposed): 547/3,968, and an OR=1.6 (95% CI:1.29) was obtained (-1.97; z= 4.31; p

 Aspirin Lactate Case-control study Vascular ischemic event