The skin is at the interface between the organism and the environment, realizing the element of unity that the totality of the organs and systems in the human body has. Through its structure and position on the human body, the skin has a main role in the economy of the whole organism; it also has an aesthetic role. The objective of this study is to assess the embryological origin, anatomical and histological structure of the skin. The skin consists of the epidermis, which is of ectodermal origin, and the dermis, which is of mesodermal origin. The most important functions of the skin are the protection, thermoregulation, control of fluid loss, immunity, and sensory perception. The source of the cutaneous vessels comes directly from arterial sources otherwise, as terminal branches of muscular vessels. Various specialized anatomical structures are placed in the skin to receive different stimuli: free nerve endings, Merkel cells, Meissner corpuscles, Pacinian corpuscles, Krause bulbs, Ruffini corpuscles, proprioceptors for cold and heat. Various post-lesion changes in the skin can affect daily activities in the sense of alienation and isolation from significant people, and in some situations, can lead to job loss, neurotic disorders, and negative social consequences.