Chronic kidney disease is a public health issue that is underappreciated and more deadly than certain other chronic illnesses. A person with CKD often has damaged kidneys, which leads to a loss of function and eventually renal. The purpose of this study was to measure the knowledge and awareness level among the general population in Saudi Arabia about chronic kidney disease. This was cross-sectional research using a questionnaire. Adult Saudi males and females who are between the ages of (18 to 60) years. Exclusion of non-Saudi population. Data was then transferred to the Statistical Package of Social-Science Software (SPSS) program, version 20. Results showed that the majority of the sample falls within the age range of 19-30, with 60.5% of the total sample falling within this category. Gender distribution shows that the sample is predominantly female, with 77.1% of the total sample being female. The p-value of 0.001 indicates a significant association between gender and knowledge and awareness of chronic kidney disease. The Makkah region has the highest number of individuals, followed by the Eastern region. The p-value of 0.001 suggests a significant association between location and knowledge and awareness of chronic kidney disease. In conclusion, despite the high incidence of the ailment, there is still a lack of public education and awareness of chronic kidney disease (CKD) in the Kingdom of Saudi Arabia. Knowledge scores were significantly associated with gender and residence place in the kingdom.