Objectives: The current study aims to observe the effect of the disease pathology on the CSF picture at admission and how the individual CSF determinants affect the patient outcome. Materials and Methods: A retrospective review of the levels of CSF glucose, protein, white blood cell count and culture in 661 cases of aneurysmal subarachnoid hemorrhage was done from the records of Thomas Jefferson University Hospital. Parameters were analyzed by student’s t test, p <0.05 is taken as significant. Results: Higher CSF glucose as well as CSF protein at admission worsened the chances of a good outcome, although CSF glucose < 40mg/dl and CSF protein < 15mg/dl at admission were associated with higher mortality. CSF white blood cell count of 3-5 /ml was associated with the best outcome, also culture negative cases had a better prognosis. Conclusions: All the CSF parameters studied gave the best prognostic results in their median values. More elaborate and prospective studies may be considered to give us a clearer picture.