Archive \ Volume.2 2011 Issue 3

Effect Of Ether Derivative Cellulose Polymers On Hydration, Erosion And Release Kinetics Of Diclofenac Sodium Matrix Tablets

Muhammad Akhlaq , Gul Majid Khan , Abdul Wahab , Waqas Rabbani , Abid Hussain , Asif Nawaz , Alam Zeb

Objectives: The work aims to investigate the effect of hydrophilic and hydrophobic polymers swelling and erosion on the release behaviour of DCL-Na from controlled matrix tablets prepared by direct compression and wet-granulation techniques. Materials and Methods: Powder preformulation studies were conducted. Tablets were prepared by direct compression technique and their physicochemical properties were evaluated. Drug-polymer interaction was analyzed by FTIR spectroscopy. The in-vitro drug release study was conducted using phosphte buffer pH 7.4 as dissolution medium and different kinetic parameters were applied. Results and Discussion: F-1 and F-5 containing ethycellulose prepared by direct compression and wet granulation techniques released 94 % and 84 % drug after 24hrs, while F-2 and F-6 containing hydroxypropylmethylcellulose polymer prepared by direct compression and wet granulation released 98.46 % and 91.25 % drug after within 24 hrs respectively. Ethylcellulose and hydroxypropylmethylcellulose based matrix tablets showed the best anomalous drug release behaviour, with the release exponents “ n ” ranging from 0.685 to 0.809. Conclusion: It has been concluded that ethylcellulose ether derivative polymer is used to prepare oral controlled release matrix tablet of diclofenac sodium. Fickian drug diffusion, polymer hydration and erosion mechanisms occurred simultaneously and were considered as the main drug release controlling factors.