Background: Quality in pathology and clinical medicine is the process of measuring efficiency at all levels of the laboratory test cycle, including pre-analytical, analytic, and post-analytical processes, to facilitate outstanding findings in medical treatment. Quality can develop productivity and production in the laboratory resulting in improved patient care and outcomes. Aim of the study: This paper aimed to overview the standards of quality of histopathology laboratory and work facilities in developed countries. Conclusion: Quality evaluation, processing, and monitoring of establishment, procedures, and activities of histopathology laboratory are essential to function effectively and safely. Guaranteeing the safety of operational personnel as well as setting is also highly significant. Quality standards of histopathology laboratory and work facilities are a must and all the standards must be applied to function effectively. A Quality Committee should be established within each histopathology laboratory to ensure routine review of quality data and to initiate improvements where required.