Introduction: The natural medicinal plants can boost self-cure, perfect health, and longevity. Acacia nilotica Lam (Acacia) is an imperative plant that possesses many medicinal uses. Acacia trees are vastly spread in Saudi Arabia. In folk medicine, various parts of Acacia tree, including the leaves, bark, seeds, roots, gum, flowers, fruits, and young pods are utilized as nutrients and therapeutic remedies to hinder, alleviate, or manage many illnesses. Acacia is wealthy in antioxidant phenolics, mainly condensed tannin and phlobatannins. Objective: This review aimed to collect the early and recently published research articles that confirmed various medicinal activities of Acacia. Results: The results obtained from the previously published studies showed that Acacia extract possesses many therapeutic effects including antimicrobial, antiparasitic, antidiabetic, antihyperlipidemic, anticancer, antimutagenic, antipyretic, anti-inflammatory, antinociceptive, antiulcer, antihypertensive, antispasmodic, antidiarrheal, and antioxidant activities. Conclusion: Acacia may become a natural, inexpensive alternative to pharmaceuticals and prescription drugs.