Archive \ Volume.14 2023 Issue 2

A Review of Polypharmacy in the Elderly and Its Management Strategies

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Abstract

With the increase in the elderly population and the increase in life expectancy, the possibility of chronic diseases and the use of several drugs at the same time has increased, which can cause harmful drug interactions and reactions. This research is a review study that was conducted by searching the keywords poly-pharmacy, elderly, and prevalence in PubMed, Science Direct, Scopus, Google Scholar, Ovid, Magiran, and Sid databases in the period of 2005-2023. According to the findings, the highest prevalence of polypharmacy was in the age groups of 70-74 and 80-84, and polypharmacy was related to the demographic characteristics and health status of the individual and the characteristics of the health center. Also, studies have shown that there is a relationship between the source of obtaining information about drugs and the polypharmacy consumption pattern. To prevent drug side effects, the necessity of continuous monitoring of elderly drugs has been emphasized in various articles. The results of the studies showed that the use of strategies such as; interaction between doctor and pharmacist, educating the elderly about the dangers of self-inflicted use of medicines, informing the elderly about the limitations of using herbal medicines, using electronic tools to monitor the process of taking medicines and using protocols and guidelines for prescribing medicines can reduce to a great extent the multiplicity of drug regimens in the drug regimen of the elderly and make the use of drugs in this age group much easier.


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Vancouver
Csep AN, Voiţă-Mekereş F, Tudoran- C, Manole F. A Review of Polypharmacy in the Elderly and Its Management Strategies. Arch Pharm Pract. 2023;14(2):106-10. https://doi.org/10.51847/eWhICm6ro1
APA
Csep, A. N., Voiţă-Mekereş, F., Tudoran-, C., & Manole, F. (2023). A Review of Polypharmacy in the Elderly and Its Management Strategies. Archives of Pharmacy Practice, 14(2), 106-110. https://doi.org/10.51847/eWhICm6ro1

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References

1.        Mahmoodi M. Polypharmacy among older adults in Tehran. Tehran Univ Med J. 2006;64(9):55-64.

2.        Bahamid AA, AlHudaithi FS, Aldawsari AN, Eyyd AK, Alsadhan NY, Alshahrani FM. Success of orthodontic space closure vs. implant in the management of missing first molar: a systematic review. Ann Dent Spec. 2022;10(4):9-14.

3.        Banerjee A, Mbamalu D, Ebrahimi S, Khan AA, Chan TF. The prevalence of polypharmacy in elderly attenders to an emergency department - a problem with a need for an effective solution. Int J Emerg Med. 2011;4(1):22.

4.        Singh GP, Attavar SH, Kavuri S. Amnion membrane matrix and bio dentine in the management of external apical root resorption. Ann Dent Spec. 2022;10(2):11-4.

5.        Haider SI, Johnell K, Thorslund M, Fastbom J. Analysis of the association between polypharmacy and socioeconomic position among elderly aged≥ 77 years in Sweden. Clin Ther. 2008;30(2):419-27.

6.        Mathew ST, ElMansy I, Khan Z, Mshaly A, Shacfe S, Alenezy N. Knowledge of safety precautions and emergency management during covid pandemic among dentists in Saudi Arabia: a cross-sectional study. Ann Dent Spec. 2022;10(1):69-77.

7.        Hussain MA, Alanazi TK, Alanazi RL, Alshammari JA, Alshammari AN, Alanazi NTM. Prevalence, Types, and Management of Maxillary Sinus Carcinoma: A Systematic Review. Clin Cancer Inv J. 2023;12(2):18-23.

8.        Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5(4):345-51.

9.        Agrawal DK, Agrawal N, Sarangdhar S, Kumari V, Narain N, Lader N, et al. Role of Altered Fractionation in Radiation Therapy with or without Chemotherapy in Management of Carcinoma Cervix: Time to Revisit in the Current COVID-19 Pandemic. Clin Cancer Inv J. 2021;10(2):53-9.

10.      Junius-Walker U, Theile G, Hummers-Pradier E. Prevalence and predictors of polypharmacy among older primary care patients in Germany. Fam Pract. 2007;24(1):14-9.

11.      Alhammad IM, Aseri AM, Alqahtani SAM, Alshaebi MF, Alqahtani ShA, Alzahrani RA, et al. A review on updates in management and Treatment of Psoriasis. Arch Pharm Pract. 2021;12(1):74-8.

12.      Nobili A, Licata G, Salerno F, Pasina L, Tettamanti M, Franchi C, et al. Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study. Eur J Clin Pharmacol. 2011;67(5):507-19.

13.      Ramzan B, Harun SN, Butt FZ, Butt RZ, Hashmi F, Gardezi Sh, et al. Impact of Diabetes Educator on Diabetes Management: Findings from Diabetes Educator Assisted Management Study of Diabetes. Arch Pharm Pract. 2022;13(2):43-50.

14.      Vetrano DL, Villani ER, Grande G, Giovannini S, Cipriani MC, Manes-Gravina E, et al. Association of polypharmacy with 1-year trajectories of cognitive and physical function in nursing home residents: results from a multicenter European study. J Am Med Dir Assoc. 2018;19(8):710-3.

15.      Fabbietti P, Di Stefano G, Moresi R, Cassetta L, Di Rosa M, Fimognari F, et al. Impact of potentially inappropriate medications and polypharmacy on 3-month readmission among older patients discharged from acute care hospital: a prospective study. Aging Clin Exp Res. 2018;30(8):977-84.

16.      Aldahshan AAS, Salamah AR, Fayoumi NM, Alkhudaydi SA, Khaled MAM, Alnahwi QAA, et al. An Overview on Post-Cholecystectomy Syndrome Diagnostic & Management Approach. Arch Pharm Pract. 2021;12(4):38-41.

17.      Beuscart JB, Petit S, Gautier S, Wierre P, Balcaen T, Lefebvre JM, et al. Polypharmacy in older patients: identifying the need for support by a community pharmacist. BMC Geriatr. 2019;19(1):1-8.

18.      Hoel RW, Connolly RMG, Takahashi PY, editors. Polypharmacy management in older patients. Mayo Clinic proceedings; 2021: Elsevier. doi:10.1016/j.mayocp.2020.06.012

19.      Algaw RK, Alnujaidi AH, Hazazi AA, Alsuwaidan MF, Homadi IA, Alqahtani OM, et al. An Overview on Gastric Cancer Surgical Management Approach. Int J Pharm Res Allied Sci. 2021;10(4):105-9.

20.      Midão L, Giardini A, Menditto E, Kardas P, Costa E. Polypharmacy prevalence among older adults based on the survey of health, aging, and retirement in Europe. Arch Gerontol Geriatr. 2018;78:213-20.

21.      Elssayed A, AlRgaiba RI, AlZalbani MK, Hassan MRJ, AlMalki KH, AlGhannam AA, et al. Review on Diagnosis and Management Approach of Multiple Sclerosis. Int J Pharm Res Allied Sci. 2023;12(1):100-5.

22.      Hosseini L, Hajibabaee F, Navab E. Reviewing polypharmacy in the elderly. Iran J Syst Rev Med Sci. 2020;1(1):15-24.

23.      McDonald EG, Wu PE, Rashidi B, Forster AJ, Huang A, Pilote L, et al. The MedSafer study: a controlled trial of an electronic decision support tool for deprescribing in acute care. J Am Geriatr Soc. 2019;67(9):1843-50.

24.      Lin HW, Lin CH, Chang CK, Chou CY, Yu IW, Lin CC, et al. Economic outcomes of pharmacist-physician medication therapy management for polypharmacy elderly: A prospective, randomized, controlled trial. J Formos Medi Assoc. 2018;117(3):235-43.

25.      Willeboordse F, Schellevis FG, Chau SH, Hugtenburg JG, Elders PJM. The effectiveness of optimized clinical medication reviews for geriatric patients: Opti-Med a cluster randomized controlled trial. Fam Pract. 2017;34(4):437-45.

26.      Wouters H, Scheper J, Koning H, Brouwer C, Twisk JW, van der Meer H, et al. Discontinuing Inappropriate Medication Use in Nursing Home Residents: ACluster Randomized Controlled Trial. Ann Intern Med. 2017;167(9):609-17.

27.      Secoli SR, Marquesini EA, Fabretti SdC, Corona LP, Romano-Lieber NS. Self-medication practice trend among the Brazilian elderly between 2006 and 2010: SABE Study. Rev Bras Epidemiol. 2019;21.

28.      Mortazavi SS, Shati M, Khankeh HR, Ahmadi F, Mehravaran S, Malakouti SK. Self-medication among the elderly in Iran: a content analysis study. BMC Geriatr. 2017;17(1):1-12.

29.      Oliveira SBVd, Barroso SCC, Bicalho MAC, Reis AMM. Profile of drugs used for self-medication by elderly attended at a referral center. Einstein (São Paulo). 2018;16. doi:10.31744/einstein_journal/2018AO4372

30.      Carmona-Torres JM, Cobo-Cuenca AI, Recio-Andrade B, Laredo-Aguilera JA, Martins MM, Rodríguez-Borrego MA. Prevalence and factors associated with polypharmacy in older people: 2006-2014. J Clin Nurs. 2018;27(15-16):2942-52.

31.      Heidari M, Borujeni MG, Ghafourifard M, Sheikhi RA. The evaluation of the awareness, attitude, and practice of the elderly toward self-medication: A cross-sectional study. Drug Res. 2018;68(08):475-80.

32.      Agbabiaka TB, Wider B, Watson LK, Goodman C. Concurrent use of prescription drugs and herbal medicinal products in older adults: a systematic review. Drugs Aging. 2017;34(12):891-905.

33.      Sun W, Tahsin F, Abbass Dick J, Barakat C, Turner J, Wilson D, et al. Educating Homecare Nurses about Deprescribing of Medications to Manage Polypharmacy for Older Adults. West J Nurs Res. 2021;43(11):1034-42.

34.      Welz AN, Emberger-Klein A, Menrad K. Why people use herbal medicine: insights from a focus-group study in Germany. BMC Complement Altern Med. 2018;18(1):1-9.

35.      Agbabiaka TB, Spencer NH, Khanom S, Goodman C. Prevalence of drug-herb and drug-supplement interactions in older adults: a cross-sectional survey. Br J Gen Pract. 2018;68(675):e711-e7.

36.      Gbeasor-Komlanvi FA, Zida-Compaore WI, Dare IH, Diallo A, Darre TP, Potchoo Y, et al. Medication consumption patterns and polypharmacy among community-dwelling elderly in lomé (Togo) in 2017. Curr Gerontol Geriatr Res. 2020;2020. doi:10.1155/2020/4346035

37.      Lavan A, Eustace J, Dahly D, Flanagan E, Gallagher P, Cullinane S, et al. Incident adverse drug reactions in geriatric inpatients: a multicentre observational study. Ther Adv Drug Saf. 2018;9(1):13-23. doi:10.1177/2042098617736191

38.      Malet-Larrea A, Goyenechea E, Gastelurrutia MA, Calvo B, García-Cárdenas V, Cabases JM, et al. Cost analysis and cost-benefit analysis of a medication review with follow-up service in aged polypharmacy patients. Eur J Health Econ. 2017;18(9):1069-78.

39.      González-Rojano E, Marcotegui J, Sampedro R, Valdez-Acosta S, Abad-Santos F. Utility of a computer tool for detection of potentially inappropriate medications in older patients in a tertiary hospital. IBJ Clin Pharmacol. 2020;1(1).

40.      Storms H, Marquet K, Aertgeerts B, Claes N. Prevalence of inappropriate medication use in residential long-term care facilities for the elderly: a systematic review. Eur J Gen Pract. 2017;23(1):69-77.

41.      Grina D, Briedis V. The use of potentially inappropriate medications among the Lithuanian elderly according to Beers and EU (7)-PIM list-a nationwide cross-sectional study on reimbursement claims data. J Clin Pharm Ther. 2017;42(2):195-200.

42.      Martin P, Tamblyn R, Benedetti A, Ahmed S, Tannenbaum C. Effect of a pharmacist-led educational intervention on inappropriate medication prescriptions in older adults: the D-PRESCRIBE randomized clinical trial. Jama. 2018;320(18):1889-98.

43.      Bonaga B, Sánchez-Jurado PM, Martínez-Reig M, Ariza G, Rodríguez-Mañas L, Gnjidic D, et al. Frailty, polypharmacy, and health outcomes in older adults: the frailty and dependence in Albacete study. J Am Med Dir Assoc. 2018;19(1):46-52.

44.      Eyigor S, Kutsal YG, Toraman F, Durmus B, Gokkaya KO, Aydeniz A, et al. Polypharmacy, physical and nutritional status, and depression in the elderly: does polypharmacy deserve some credit for these problems? Exp Aging Res. 2021;47(1):79-91.

45.      Locquet M, Honvo G, Rabenda V, Van Hees T, Petermans J, Reginster JY, et al. Adverse health events related to self-medication practices among elderly: a systematic review. Drugs Aging. 2017;34(5):359-65.

46.      Hamm RM, Nagykaldi ZJ. Physician judgment and clinical practice guidelines. J Cogn Eng Decis Mak. 2018;12(3):209-14.

47.      Harrison S, Kouladjian O’Donnell L, Milte R, Dyer S, Gnanamanickam E, Bradley C, et al. Costs of potentially inappropriate medication use in residential aged care facilities. BMC Geriatr. 2018;18(1):1-10.


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