Scientists have recently paid a lot of attention to the use of dendrimers in biomedicine. The properties of dendrimers, such as their branching, well-defined globular structures, excellent structural regularity, multivalency, diverse chemical composition, and great biological compatibility, make them appealing for biomedical applications. Several biologically active substances can be incorporated into the three-dimensional structure of dendrimers to create biologically active conjugates. First, a brief overview of dendrimers is given in this state-of-art review, with an emphasis on Poly(amidoamine) (PAMAM) dendrimers and optical sensors. Dendrimers are a newer type of monodisperse polymer with tree-like spherical structures and well-defined sizes and forms. Their peculiar structure significantly affects both their chemical and physical characteristics. PAMAM dendrimer-based optical sensors, employed for the detection of pH, cations, and other analytes, have recently seen advancements, according to reports. Due to its robust synthesis, availability, dendritic structure, and peptide/protein mimic properties, poly(amidoamine) (PAMAM) dendrimers have received the most research attention of all the dendrimers that have been described. The current review is thorough and addresses a different generation of PAMAM dendrimer and related aspects, including i) properties, ii) synthesis, and iii) characterization. The focus is on their uses as well as the state of ongoing medication targeting research at the moment.
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