Background: Diabetes is a highly prevalent disease, with its complications strongly correlating to the glycemic control of patients. Objectives: We aimed to review the literature for recent advances in the prognosis and management of diabetic foot ulceration. Methodology: PubMed database was used for articles selection. Papers were obtained and reviewed. PubMed database was used for articles selection, and the following keys terms were used: diabetic foot ulcer, prognosis, and management. Conclusion: Not all managed cases were cured, and some develop resistance to traditional methods and would require unconventional therapies. Nevertheless, this should not deter the physician from offering treatment as this improves prognosis.