Archive \ Volume.13 2022 Issue 2

Coenzyme Q10 regulates Gene expression of Myocardial Infarction in Isoproterenol Model

Ahmed O. Babalghith

Cardiac remodeling is defined by changes in the genome's expression, as well as molecular, cellular, and interstitial state alterations, all of which lead to changes in the heart's function. Coenzyme Q10 (CoQ10) is increasingly the most critical component of mitochondria's electron transport chain, which is required for ATP generation. The main intent of this scrutiny is to assess CoQ10's role in myocardial infarction (MI) in male rats. The rats were split into four factions: the controls (C), the CoQ10 treated batch, ISO treated batch and CoQ10+ISO treated batch. Biochemical markers of liver functions (AST, ALT, ALP, albumin, and total protein), cardiac markers, electrolytes, TNF, oxidative stress [malondialdehyde (MDA)], and antioxidative [superoxide dismutase (SOD), and reduced glutathione (GSH)] were all examined. qPCR was used to assess the cardiac tissues expression of the the angiogenesis-related gene vascular endothelial growth factor (VEGF), the migration-related gene matrix metalloprotease 9 (MMP9), and the antioxidant-related gene Heme Oxygenase-1 (HO-1). CoQ10 treatment of ISO-bearing rats reduced hepatic damage as shown by restored liver function measures, reduced cardiac MDA levels, increased cardiac GSH and SOD levels, upregulated expression of VEGF, MMP9, and HO-1. It’s concluded that CoQ10 played a preventive function against heart injury generated by the ISO model based on these findings.

Downloads: 49
Views: 49

How to cite:
Babalghith AO. Coenzyme Q10 regulates Gene expression of Myocardial Infarction in Isoproterenol Model. Arch Pharm Pract. 2022;13(2):1-6.
Babalghith, A. O. (2022). Coenzyme Q10 regulates Gene expression of Myocardial Infarction in Isoproterenol Model. Archives of Pharmacy Practice, 13(2), 1-6.

Download Citation

1.        Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Am Coll Cardiol. 2020;76(25):2982-3021.

2.        Golforoush P, Yellon DM, Davidson SM. Mouse models of atherosclerosis and their suitability for the study of myocardial infarction. Basic Res Cardiol. 2020;115(6):1-24.

3.        Hyun K, Negrone A, Redfern J, Atkins E, Chow C, Kilian J, et al. Gender difference in secondary prevention of cardiovascular disease and outcomes following the survival of acute coronary syndrome. Heart Lung Circ. 2021;30(1):121-7‏.

4.        Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Ischemia/reperfusion. Compr Physiol. 2016;7(1):113.

5.        Torrealba N, Aranguiz P, Alonso C, Rothermel BA, Lavandero S. Mitochondria in structural and functional cardiac remodeling. Mitochondrial Dyn Cardiovasc Med. 2017:277-306.

6.        Derbali A, Mnafgui K, Affes M, Derbali F, Hajji R, Gharsallah N, et al. Cardioprotective effect of linseed oil against isoproterenol-induced myocardial infarction in Wistar rats: a biochemical and electrocardiographic study. J Physiol Biochem. 2015;71(2):281-8.

7.        Neri M, Fineschi V, Di Paolo M, Pomara C, Riezzo I, Turillazzi E, et al. Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction. Curr Vasc Pharmacol. 2015;13(1):26-36.

8.        Tauffenberger A, Magistretti PJ. Reactive oxygen species: beyond their reactive behavior. Neurochem Res. 2021;46(1):77-87‏.

9.        Ulla A, Mohamed MK, Sikder B, Rahman AFMT, Sumi FA, Hossain M, et al. Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats. BMC Pharmacol Toxicol. 2017;18(1):1-10.

10.      Alam MA, Rahman MM. Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome. J Diabetes Metab Disord. 2014;13(1):1-11.

11.      Lobo Filho HG, Ferreira NL, Sousa RB de, Carvalho ER de, Lobo PLD, Lobo Filho JG. Experimental model of myocardial infarction induced by isoproterenol in rats. Brazilian J Cardiovasc Surg. 2011;26:469-76.

12.      Bujak M, Kweon HJ, Chatila K, Li N, Taffet G, Frangogiannis NG. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol. 2008;51(14):1384-92.

13.      Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007;37(1):31-7.

14.      Krenek P, Kmecova J, Kucerova D, Bajuszova Z, Musil P, Gazova A, et al. Isoproterenol‐induced heart failure in the rat is associated with nitric oxide‐dependent functional alterations of cardiac function. Eur J Heart Fail. 2009;11(2):140-6.

15.      Sumi FA, Sikder B, Rahman MM, Lubna SR, Ulla A, Hossain MH, et al. Phenolic content analysis of aloe vera gel and evaluation of the effect of aloe gel supplementation on oxidative stress and fibrosis in isoprenaline-administered cardiac damage in rats. Prev Nutr Food Sci. 2019;24(3):254.

16.      Barman NR, Nandy S, Datta R, Kar PK. Cardioprotective effect of ethanolic extract of Urtica parviflora Roxb. against isoproterenol-induced myocardial infarction in rats. Indian J Pharmacol. 2013;45(5):513.

17.      Veisi S, Johari SA, Tyler CR, Mansouri B, Esmaeilbeigi M. Antioxidant properties of dietary supplements of free and nanoencapsulated silymarin and their ameliorative effects on silver nanoparticles induced oxidative stress in Nile tilapia (Oreochromis niloticus). Environ Sci Pollut Res. 2021;28(20):26055-63.

18.      Omnia M, Elhamid A, Hatem B, Rania HM, Elnaga A. Biochemical effect of garlic oil administration in heart necrosis induced experimentally in rats. Benha Vet Med J. 2014;27:264-76.

19.      Elasoru SE, Rhana P, de Oliveira Barreto T, de Souza DLN, Menezes-Filho JER, Souza DS, et al. Andrographolide protects against isoproterenol-induced myocardial infarction in rats through inhibition of L-type Ca2+ and increase of cardiac transient outward K+ currents. Eur J Pharmacol. 2021;906:174194.‏

20.      Lekshmi VS, Kurup GM. Sulfated polysaccharides from the edible marine algae Padina tetrastromatica protects the heart by ameliorating hyperlipidemia, endothelial dysfunction, and inflammation in isoproterenol-induced experimental myocardial infarction. J Funct Foods. 2019;54:22-31.

21.      Jain PG, Mahajan UB, Shinde SD, Surana SJ. Cardioprotective role of FA against isoproterenol-induced cardiac toxicity. Mol Biol Rep. 2018;45(5):1357-65.

22.      Wu YW, Ho SK, Tseng WK, Yeh HI, Leu HB, Yin WH, et al. Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease. Sci Rep. 2020;10(1):1-9.

23.      Attalla DM, Ahmed LA, Zaki HF, Khattab MM. Paradoxical effects of atorvastatin in isoproterenol-induced cardiotoxicity in rats: role of oxidative stress and inflammation. Biomed Pharmacother. 2018;104:542-9.

24.      Ghule AE, Kulkarni CP, Bodhankar SL, Pandit VA. Effect of pretreatment with coenzyme Q10 on isoproterenol-induced cardiotoxicity and cardiac hypertrophy in rats. Curr Ther Res. 2009;70(6):460-71.

25.      MacCarthy PA, Shah AM. Oxidative stress and heart failure. Coron Artery Dis. 2003;14(2):109-13.

26.      Moßhammer D, Schaeffeler E, Schwab M, Mörike K. Mechanisms and assessment of statin‐related muscular adverse effects. Br J Clin Pharmacol. 2014;78(3):454-66.

27.      Eftekhari A, Ahmadian E, Azarmi Y, Parvizpur A, Hamishehkar H, Eghbal MA. In Vitro/Vivo studies towards mechanisms of risperidone-induced oxidative stress and the protective role of coenzyme Q10 and N-acetylcysteine. Toxicol Mech Methods. 2016;26(7):520-8.

28.      Costa TJ, Barros PR, Arce C, Santos JD, da Silva-Neto J, Egea G, et al. The homeostatic role of hydrogen peroxide, superoxide anion and nitric oxide in the vasculature. Free Radic Biol Med. 2021;162:615-35.

29.      Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Jazayeri S, Reza Gohari M. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. Int J Neurosci. 2013;123(11):776-82.

30.      Khodir AE, Atef H, Said E, ElKashef HA, Salem HA. Implication of Nrf2/HO-1 pathway in the coloprotective effect of coenzyme Q10 against experimentally induced ulcerative colitis. Inflammopharmacology. 2017;25(1):119-35.

31.      Pala R, Orhan C, Tuzcu M, Sahin N, Ali S, Cinar V, et al. Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 pathways in exercise training. J Sports Sci Med. 2016;15(1):196.

32.      Bahar M, Khaghani S, Pasalar P, Paknejad M, Khorramizadeh MR, Mirmiranpour H, et al. Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model. Nutr J. 2010;9(1):1-8.

33.      Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Khodadadi B, Jazayeri S, et al. Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double-blind, placebo, controlled randomized clinical trial. Nutr Neurosci. 2015;18(4):169-76.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.