Coenzyme Q10 regulates Gene expression of Myocardial Infarction in Isoproterenol Model

Cardiac remodeling is defined by changes in the genome's expression, as well as molecular, cellular, and interstitial state alterations, all of which lead to changes in the heart's function. Coenzyme Q10 (CoQ10) is increasingly the most critical component of mitochondria's electron transport chain, which is required for ATP generation. The main intent of this scrutiny is to assess CoQ10's role in myocardial infarction (MI) in male rats. The rats were split into four factions: the controls (C), the CoQ10 treated batch, ISO treated batch and CoQ10+ISO treated batch. Biochemical markers of liver functions (AST, ALT, ALP, albumin, and total protein), cardiac markers, electrolytes, TNF, oxidative stress [malondialdehyde (MDA)], and antioxidative [superoxide dismutase (SOD), and reduced glutathione (GSH)] were all examined. qPCR was used to assess the cardiac tissues expression of the the angiogenesis-related gene vascular endothelial growth factor (VEGF), the migration-related gene matrix metalloprotease 9 (MMP9), and the antioxidant-related gene Heme Oxygenase-1 (HO-1). CoQ10 treatment of ISO-bearing rats reduced hepatic damage as shown by restored liver function measures, reduced cardiac MDA levels, increased cardiac GSH and SOD levels, upregulated expression of VEGF, MMP9, and HO-1. It’s concluded that CoQ10 played a preventive function against heart injury generated by the ISO model based on these findings.

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