Archive \ Volume.14 2023 Issue 4

Comorbidity of Mental and Somatic Pathology in the Study of the Association of Blood Folate Levels

Khizir Mukhidinovich Bataev , Imran Sulumbekovich Avduev , Medina Khizirovna Bataeva , Ahmed Dokkaevich Chupalaev , Malika Abdulbakievna Todasheva , Abdula Timurovich Bachigov , Luiza Hadjimuratovna Irisbaeva , Eliza Shakhrudinovna Saralieva

Abstract

This research work focuses on comorbidity, which links a complex of somatic and mental pathologies in patients with diagnosed bipolar personality disorder and the development of cardiovascular catastrophe in the form of ischemic stroke. The authors consider it promising and relevant to study the role of deficiencies of certain nutrients and the influence of this factor on the appearance and development of various mental disorders, in particular, the level of folate in the blood serum to prevent the development of cardiovascular catastrophe in patients with bipolar personality disorder. The core of the randomized study included 18 patients with diagnosed bipolar disorder and 20 healthy people with a history of ischemic stroke by mental status. The practical results of the work confirm the current literature data on a decrease in the concentration of folates in the blood of patients with bipolar disorder and diagnosed ischemic stroke, which proves the relationship between the mental and somatic components and impaired metabolism of folic acid derivatives. The information obtained should serve as a trigger for the search for an evidence-based strategy for managing this cohort of patients in the key point prevention and correction of the existing disease.


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Vancouver
Bataev KM, Avduev IS, Bataeva MK, Chupalaev AD, Todasheva MA, Bachigov AT, et al. Comorbidity of Mental and Somatic Pathology in the Study of the Association of Blood Folate Levels. Arch Pharm Pract. 2023;14(4):127-30. https://doi.org/10.51847/hncIfGEkHN
APA
Bataev, K. M., Avduev, I. S., Bataeva, M. K., Chupalaev, A. D., Todasheva, M. A., Bachigov, A. T., Irisbaeva, L. H., & Saralieva, E. S. (2023). Comorbidity of Mental and Somatic Pathology in the Study of the Association of Blood Folate Levels. Archives of Pharmacy Practice, 14(4), 127-130. https://doi.org/10.51847/hncIfGEkHN

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References
  1. Sharma S, Magar PT, Achhami S, Hamal P, Chapagain B, Jaiswal S, et al. Bacterial profiling and antibiotic-resistant pattern among cancer patients. Clin Cancer Investig J. 2022;11(2):14-20.
  2. Jayavel K, Sivagnanam S. The Current Scenario Regarding the Narrative Advancement of Oral Cancer. Clin Cancer Investig J. 2022;11(2):7-13.
  3. Shetty B, Chauhan RS, Vishwas P, Rathi N, Krishnapriya N, Tirupathi S. Antimicrobial Efficacy of Curcumin Modified Zinc Oxide Eugenol Against Endodontic Pathogens. Ann Dent Spec. 2022;10(1):47-51.
  4. Balaji A, Jei JB, Murugesan K, Muthukumar B. Rehabilitation of Distal Extension Edentulous Case with Claspless Extra-Coronal Attachments- A Case Report. Ann Dent Spec. 2022;10(2):1-4.
  5. Maralov VG, Sitarov VA, Koryagina II, Kudaka MA, Smirnova OV, Romanyuk LV. The Relationship of Neuropsychological and Personal Factors with The Attitude to Dangers Among Students. J Organ Behav Res. 2022;7(1):108-24.
  6. Abu-Awwad A, Tudoran C, Patrascu Jr JM, Faur C, Tudoran M, Mekeres GM, et al. Unexpected Repercussions of the COVID-19 Pandemic on Total Hip Arthroplasty with Cemented Hip Prosthesis versus Cementless Implants. Materials. 2023;16(4):1640.
  7. Voiță-Mekereș F, Voiță GF, Pogan MD, Delcea C, Manole F, Mekereș GM, et al. Clinical Considerations of Dental Longevity from the Lateral Area. Pharmacophore. 2023;14(3).
  8. Massie MJ. Prevalence of depression in patients with cancer. J Natl Cancer Inst Monogr. 2004;(32):57-71. doi:10.1093/jncimonographs/lgh014
  9. Perry BI, Bowker N, Burgess S, Wareham NJ, Upthegrove R, Jones PB, et al. Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses. Schizophr Bull Open. 2022;3(1):sgac001. doi:10.1093/schizbullopen/sgac001
  10. Golimbet VE, Klyushnik TP. Genome-wide studies of comorbidity of somatic and mental diseases. Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(4. Vyp. 2):60-4. Russian. doi:10.17116/jnevro202312304260
  11. Watanabe K, Stringer S, Frei O, Umićević Mirkov M, de Leeuw C, Polderman TJC, et al. A global overview of pleiotropy and genetic architecture in complex traits. Nat Genet. 2019;51(9):1339-48. doi:10.1038/s41588-019-0481-0
  12. Ji HF, Zhuang QS, Shen L. Genetic overlap between type 2 diabetes and major depressive disorder identified by bioinformatics analysis. Oncotarget. 2016;7(14):17410-4. doi:10.18632/oncotarget.8202
  13. Rodriguez-Paris D, Remlinger-Molenda A, Kurzawa R, Głowińska A, Spaczyński R, Rybakowski F, et al. Psychiatric disorders in women with polycystic ovary syndrome. Psychiatr Pol. 2019;53(4):955-66. English, Polish. doi:10.12740/PP/OnlineFirst/93105
  14. Marucci S, Ragione LD, De Iaco G, Mococci T, Vicini M, Guastamacchia E, et al. Anorexia Nervosa and Comorbid Psychopathology. Endocr Metab Immune Disord Drug Targets. 2018;18(4):316-24. doi:10.2174/1871530318666180213111637
  15. Lu D, Song J, Lu Y, Fall K, Chen X, Fang F, et al. A shared genetic contribution to breast cancer and schizophrenia. Nat Commun. 2020;11(1):4637. doi:10.1038/s41467-020-18492-8
  16. Dantzer R. Psychoneuroendocrinology in 2022. Psychoneuroendocrinology. 2022;143:105865. doi:10.1016/j.psyneuen.2022.105865
  17. Leedom LJ, Meehan WP. The psychoneuroendocrinology of diabetes mellitus in rodents. Psychoneuroendocrinology. 1989;14(4):275-94. doi:10.1016/0306-4530(89)90030-9
  18. Torgersen K, Rahman Z, Bahrami S, Hindley GFL, Parker N, Frei O, et al. Shared genetic loci between depression and cardiometabolic traits. PLoS Genet. 2022;18(5):e1010161. doi:10.1371/journal.pgen.1010161
  19. Cao H, Li S, Baranova A, Zhang F. Shared Genetic Liability Between Major Depressive Disorder and Atopic Diseases. Front Immunol. 2021;12:665160. doi:10.3389/fimmu.2021.665160
  20. Fanelli G, Franke B, De Witte W, Ruisch IH, Haavik J, van Gils V, et al. Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders. Transl Psychiatry. 2022;12(1):59. doi:10.1038/s41398-022-01817-0
  21. Ogawa Y, Tajika A, Takeshima N, Hayasaka Y, Furukawa TA. Mood stabilizers and antipsychotics for acute mania: a systematic review and meta-analysis of combination/augmentation therapy versus monotherapy. CNS Drugs. 2014;28:989-1003.
  22. Cipriani A, Barbui C, Salanti G, Rendell J, Brown R, Stockton S, et al. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet. 2011;378(9799):1306-15.
  23. Castro K, Klein Lda S, Baronio D, Gottfried C, Riesgo R, Perry IS. Folic acid and autism: What do we know? Nutr Neurosci. 2016;19(7):310-7. doi:10.1179/1476830514Y.0000000142
  24. Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol. 2005;19(1):59-65. doi:10.1177/0269881105048899
  25. Sahu P, Thippeswamy H, Chaturvedi SK. Neuropsychiatric manifestations in vitamin B12 deficiency. Vitam Horm. 2022;119:457-70. doi:10.1016/bs.vh.2022.01.001
  26. Jin X, Cheng Z, Yu X, Tao Q, Huang R, Wang S. Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression-A meta-analysis. J Affect Disord. 2022;302:258-72. doi:10.1016/j.jad.2022.01.080
  27. Zhilyaeva TV, Kasyanov ED, Pyatoykina AS, Blagonravova AS, Mazo GE. The association of serum folate levels with schizophrenia symptoms. Zh. Nevrol. Psikhiatr. 2022;122(8):128-35. (In Russ.) doi:10.17116/jnevro2022122081128
  28. Łojko D, Stelmach-Mardas M, Suwalska A. Is diet important in bipolar disorder? Psychiatr Pol. 2018;52(5):783-95. English, Polish. doi:10.12740/PP/OnlineFirst/78703
  29. Gabriel FC, Oliveira M, Bruna De M Martella, Berk M, Brietzke E, Jacka FN, et al. Nutrition and bipolar disorder: a systematic review. Nutr Neurosci. 2023;26(7):637-51. doi:10.1080/1028415X.2022.2077031
  30. Mitchell ES, Conus N, Kaput J. B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder, and cognitive decline. Neurosci Biobehav Rev. 2014;47:307-20. doi:10.1016/j.neubiorev.2014.08.006
  31. Amare AT, Schubert KO, Klingler-Hoffmann M, Cohen-Woods S, Baune BT. The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome-wide and candidate gene studies. Transl Psychiatry. 2017;7(1):e1007. doi:10.1038/tp.2016.261
  32. Blinov AV, Nagdalian AA, Povetkin SN, Gvozdenko AA, Verevkina MN, Rzhepakovsky IV, et al. Surface-oxidized polymer-stabilized Silver Nanoparticles as a Covering Component of Suture Materials. Micromachines. 2022;13(7):1105. doi:10.3390/mi13071105
  33. Maslova AY, Tskaeva AA, Ashurova ZA, Abazova A, Ismailov MM, Ismailova MM. Study of the Effect of Baricitinib on the Course of COVID-19. J Pharm Res Int. 2021;33(35):204-13.

 

 

 

 


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