Several COVID-19 vaccines have been developed and authorized for emergency use by various regulatory agencies worldwide. Objective: to compare the adverse effects and safety of confirmed COVID-19 vaccines in Saudi Arabia and provide a centralized database of suspected adverse reactions and safety profiles to these vaccines. In this cross-sectional study, the study was conducted among the 633 vaccinated participants living in Saudi Arabia through an online questionnaire. Their age group was between 15-85 years old. The study indicated that 55% of the participants were infected with COVID-19, and 33% were infected before vaccination. 10% of our study participants had two or more related comorbidities, commonly hypertension, respiratory problems, and diabetes mellitus. The most frequent side effects of these vaccines are fatigue, headaches, fever, myalgia, arthralgia, pain, tenderness, and swelling at the injection site, especially after the first dose. Commonly systemic side effects presented in young female participants, 15-30 years old. This study postulates a database about the possibility of developing COVID-19 vaccine adverse effects based on age, gender, comorbidities, and vaccine type. More research must be done to understand more clearly the association between developing adverse effects and risk factors.
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