Generally, virtual reality training (VRT) has been used for the neurosomatic patients to treat the balance problems. The practical application about the effective implementation of this training in osteoporotic post-menopausal women is lacking in medical field. The aim of this study is to find the effects of virtual reality training in bone mineral density, bone mineral content and the quality of life in osteoporotic post-menopausal women. This is a study with an experimental design. 45 participants were equally divided into virtual reality training group VRT-G (n=15), multi-exercise training group MET-G (n=15) and control (n=15) group and undergone 12 weeks of training program. Bone mineral density, bone mineral content and the quality of life were measured before and after 12 weeks of training program. After the training, VRT group shows more significant changes in bone mineral density and bone mineral content than the other two groups (p<0.05). Quality of life measures such as pain, activities of daily living, jobs around the house, mobility, leisure & social activities, general health perception and mental function also showed more improvement in VRT group than the other two groups (p<0.05). The study reported that virtual reality training has wide beneficial effects on bone mineral density, bone mineral content and quality of effect in post-menopause osteoporotic women which may also reduce the risk of osteoporotic fracture.