Bleaching one's teeth is a less invasive alternative to getting aesthetic related work done. Although bleaching is safe when in contact with teeth and related tissues, some are still worried about its potential side effects. It is stated that the bleaching procedure must be employed according to a particular diagnostic, taking into consideration various aspects such as the following: kind of discoloration, condition of teeth produced by food, quantity of reagents used, age, kind of reactions to chemical compounds used, and time it is applied. A systematic literature review from 2012 to 2022 was performed using databases such as PubMed, Medline and ScienceDirect. The keywords used were “bleaching”, “carbamide peroxide”, “10% carbamide peroxide”, “30% carbamide peroxide”. Some studies reported 10-16% carbamide peroxide to be effective, whereas some stated otherwise. Some studies showed that using 35% CP bleaching gels had no effect on the surface roughness of composite resin. The result reveals that 10 and 16% are more effective than the 37% concentration in one week of treatment. Low concentration is enough to produced good results without the risk of any adverse effects. Both ranges of carbamide peroxide concentrations resulted in color change. However, high concentration often led to surface roughness that may support S. mutans deposition. Low concentration is enough to produced good results without the risk of any adverse effects.
1. Harouak H, Ibijbijen J, Nassiri L. Comparison between Medicinal Plants Used Against Oral Diseases and Pharmaceutical Dental Products In Morocco. Ann Dent Spec. 2019;7(2):1-4.
2. Yamany IA. The Employment of CBCT in Assessing Bone Loss around Dental Implants in Patients Receiving Mandibular Implant Supported over dentures. Int J Pharm Res Allied Sci. 2019;8(3):9-16.
3. Nancy A, Sukinah A, Maram A, Sara A, Hiba A, Manar A. Dental and Skeletal Manifestation of Sickle-Cell Anaemia and Thalassemia in Saudi Arabia; A Systematic Review. Int J Pharm Res Allied Sci. 2021;10(3):1-7.
4. Favoreto MW, Hass V, Maran BM, de Paula E, Wachter F, Lima SN, et al. At-home Bleaching with a Novel Carbamide Peroxide Polymeric Nanoparticle Gel: A Multicenter Randomized Controlled Trial. Oper Dent. 2022;47(5):492-502.
5. Jafari NE, Ajami AA, Savadi OS, Abed KM, Bahari M, Ebrahimi CM, et al. Surface Roughness of Different Composite Resins After Application of 15% Carbamide Peroxide and Brushing with Toothpaste: An In-Vitro Study. 2019;16(1):58-63.
6. Kimyai S, Lahij YG, Daneshpooy M, Navimipour EJ, Oskoee PA. Comparison of the effect of bleaching with 15% carbamide peroxide on the flexural strength of three resin-based restorative materials. Front Dent. 2020;17.
7. Mohammadi N, Kimyai S, Lahij YG, Bahari M, Ajami AA, Kahnamouei MA, et al. Correction to: Comparison of the effect of bleaching with 15% carbamide peroxide and 35% hydrogen peroxide on flexural strength of Cention N in self-cured and dual-cured polymerization modes. J Dent Res Dent Clin Dent Prospects. 2020;14(4):262.
8. Demir N, Karci M, Ozcan M. Effects of 16% carbamide peroxide bleaching on the surface properties of glazed glassy matrix ceramics. BioMed Res Int. 2020;2020.
9. Seleem D, Dadjoo S, Ha A, Santos C, Mirfarsi S, Matsumura-Lem K, et al. Effect of 10% Carbamide Peroxide on Tooth Shade, Plaque Index and Gingival Index during Invisalign Treatment. Dent J. 2021;9(5):48.
10. Nathan KB, Nadig RR, Job TV, Nithin PV, Karthik R, Choudary S. Radicular Peroxide Penetration from Different Concentrations of Carbamide Peroxide Gel during Intracoronal Bleaching-An In vitro Study. J Contemp Dent Pract. 2019;20(5):587-92.
11. Sutil E, da Silva KL, Terra RMO, Burey A, Rezende M, Reis A, et al. Effectiveness and adverse effects of at‐home dental bleaching with 37% versus 10% carbamide peroxide: A randomized, blind clinical trial. J Esthet Restor Dent. 2022;34(2):313-21.
12. Anggakusuma KN, Pratiwi D, Widyarman AS. The effect of carbamide peroxide on surface enamel structural changes and streptococcus mutans attachment. Sci Dent J. 2020;4(1):6.
13. Meireles SS, Fontes ST, Coimbra LAA, Bona ÁD, Demarco FF. Effectiveness of different carbamide peroxide concentrations used for tooth bleaching: an in vitro study. J Appl Oral Sci. 2012;20:186-91.
14. Sadeghloo S, Ezoji F, Nikkhah F, Gholinia H. The effect of different concentrations of carbamide peroxide on the marginal seal of composite restorations bonded with a self-etch adhesive. Caspian J Dent Res. 2016;5:36-42.
15. Knežević N, Dolić O, Obradović M, Kojić Ž, Đeri A, Veselinović V, et al. The degree of tooth color change using different concentrations of carbamide peroxide. Scr Med. 2019;50(4):161-6.
16. Luque-Martinez I, Reis A, Schroeder M, Muñoz MA, Loguercio AD, Masterson D, et al. Comparison of efficacy of tray-delivered carbamide and hydrogen peroxide for at-home bleaching: a systematic review and meta-analysis. Clin Oral Investig. 2016;20(7):1419-33.
17. Moosavi H, Ghavamnasiri M, Manari V. Effect of postoperative bleaching on marginal leakage of resin composite and resin-modified glass ionomer restorations at different delayed periods of exposure to carbamide peroxide. J Contemp Dent Pract. 2009;10(6):E009-16.
18. Delfino CS, Chinelatti MA, Carrasco-Guerisoli LD, Batista AR, Fröner IC, Palma-Dibb RG. Effectiveness of home bleaching agents in discolored teeth and influence on enamel microhardness. J Appl Oral Sci. 2009;17:284-8.
19. Goldberg M, Grootveld M, Lynch E. Undesirable and adverse effects of tooth-whitening products: a review. Clin Oral Investig. 2010;14(1):1-10.
20. Sharafeddin F, Jamalipour G. Effects of 35% carbamide peroxide gel on surface roughness and hardness of composite resins. J Dent. 2010;7(1):6.
21. Lim M, Lum S, Poh R, Lee G, Lim KC. An in vitro comparison of the bleaching efficacy of 35% carbamide peroxide with established intracoronal bleaching agents. Int Endod J. 2004;37(7):483-8.
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