Introduction: Deep Vein Thrombosis (DVT) is a common disease and is a subset of venous thromboembolism (VTE). It is a significant preventable cause of mortality and morbidity in the world. Anticoagulant therapeutic approaches such as heparin and also vitamin K antagonists were introduced during the early 20th century. The development of surgical thrombectomy and new vena cava clips treatments were promoted to reduce mortality and avoid unexpected complications. Moreover, new strategies have evolved to diagnose this condition. Methodology: PubMed published data was used for articles selection and using the following keys in the mesh ((‘’DVT’’[Mesh])), ((‘’VTE ’’[Mesh])) ((‘’Deep Venous Thrombosis ’’[Mesh])), ((‘’Venous’’[Mesh])). Conclusion: DVT is an annoying and prevalent problem for clinicians and it is important to promote diagnosis and treatment. Although the safety profile of DOACs has been quite favorable, dabigatran and rivaroxaban increase the risk of GI bleeding in patients, and further research is necessary.