The first study of the anticoagulant effect of Cucumis melon rind powder extracts is herein reported. The anticoagulant potency of melon (Cucumis melo) rind powder (MRP) extracts has been explored using the cephalin kaolin time (TCK) test and the Quick time (TQ) test. The extraction was performed using three solvents (methanol, acetone, and n-butanol) at 80 %, in addition to distilled water. Results have shown that the aqueous extract had no anticoagulant capacity, while the methanolic and acetonic extracts had heparin-like anticoagulant activity. The anticoagulant effect was observed on the endogenous, exogenous, and common pathways of coagulation with a highly marked effect on the exogenous pathway than on the endogenous pathway. Butanolic extract had a very significant (p ˂ 0.05) anticoagulant activity which shows promise as an alternative anticoagulant therapy. This study, the first of its kind had evidenced the anticoagulant abilities of Cucumis Melo rinds. Therefore, this by-product could be deployed in medicine to manage and control bleeding and blood coagulation disorders.
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