Background: The infections caused by Staphylococcus aureus, are emerging as a major public health concern. Antibiotic resistance in these isolates makes the treatment procedure harder and costlier. The aim of this study was to determine the frequency of fnbA, fnbB, hla and cna genes and antibiotic susceptibility pattern in Staphylococcus aureus isolates collected from blood cultures. Material and Methods: Totally, 100 Staphylococcus aureus isolates were collected from blood cultures at four university hospitals in Tabriz. Susceptibility patterns of isolates to antibiotics including erythromycin, clindamycin, ciprofloxacin, cefoxitin, gentamicin, cotrimoxazole, and linezolid were determined by disk diffusion agar and susceptibility of isolates to vancomycin were identified by microbroth dilution method. The frequency of the fnbA, fnbB, hla and cna genes was evaluated through the PCR as well. In addition, the molecular typing of isolates was performed by rep-PCR. Results: A high susceptibility rate to vancomycin, linezolid and cotrimoxazole in isolates was observed, while, erythromycin and clindamycin had the lowest efficiency to deal with infections. Totally, 81%, 81%, 73%, and 30% of isolates were containing the fnbA, fnbB, cna, and hla genes, respectively. Conclusion: In addition to vancomycin, linezolid and cotrimoxazole have the potency to be prescribed in the treatment course of staphylococcal infections.
Copyright © 2026 Archives of Pharmacy Practice. Authors retain copyright of their article if they are accepted for publication.
Developed by Archives of Pharmacy Practice
