Impact of Bromelain on wound healing and complications after periodontal surgery

Background: we intend to examine the effect of Bromelain on the wound healing after periodontal surgery. Methods: In this split mouth study, we selected 20 patients with generalized moderate to severe chronic periodontitis requiring periodontal surgery and referred to the periodontology section of the Mashhad Dental Faculty. Then, we randomly considered one side of the mandible as the control group and the other side as the case group, Bromelain and placebo tablets was prescribed for case and control sides respectively; 3 tablets per day from day 1st to 3rd and 2 tablets per day from day 4th to 7th after surgery. Then REEDA index (Redness, edema, ecchymosis, discharge from the wound, approximation), VAS scale (Visual Analog Scale) in the day 3th and 7th after surgery and GI (Gingival Index) in day 7th and 14th were measured. The obtained data was analyzed using SPSS software and statistical tests of Kolmogorov-Smirnov, Friedman, Wilcoxon and Mann-Whitney. Results: Following data analysis, we found that none of REEDA indices such as edema, Redness, discharge, ecchymosis and GI had significant difference between two groups and only the VAS diagram has a significant difference between case and control group (P-value<0.05). Conclusion: According to the present study, we suggest that use of Bromelain after Periodontal surgery has a significant effect on pain reduction but wouldn’t result in decreasing of inflammation and accelerating wound healing.