Incidences and Etiology of Breast Cancer, on the basis of CYP450 Genes Polymorphisms

Breast carcinoma is the most predominant malignancy in women and stands as the second leading (15%) of cancer death amongst females. Breast cancer is one-fourth of female cancer cases worldwide with 200,000 cases in the United States of America which includes twenty-seven percent of all cancers in females; 320,000 cases in Europe which include thirty-one percent of all cancers in females. It is the 2nd reason for death among Iranian females, and one million new cases are diagnosed worldwide annually. Breast cancer accounted for twenty-six percent of all female cancers with a crude incidence rate of twenty-three percent in 100 thousand in Tehran province. During the last four decades, its enhancing incidence rate has made breast cancer one of the most dominant malignancies among Iranian women. In a descriptive cross-sectional investigation, a four-year period medical existing data associated with the pathology center in Tehran were evaluated. Data were extracted and clinical and other variables were contrasted between benign and malignant lesions. Findings revealed that the mean (± standard deviation) age was forty-two years. In four hundred cases (36%) the lesions were malignant and in seven hundred cases (64%) those were benign. The most common kinds of benign lesions were fibrocystic modifications (43%) and Adenofibroma (28%) and the most prevalent malignancy was invasive ductal carcinoma (88%). In this review article, incidences and etiology of breast cancer risks on the basis of CYP450 genes polymorphisms have been investigated.