Archive \ Volume.12 2021 Issue 1

Investigating endurance training with ergometer bicycle in changes the plasma levels of chemerin on overweight women

Ahmad R. A. Ashtiani , Rezvane Galdavi , Mehri Jafari

Background and Purpose: Adipokine chemerin is a pre-inflammation associated with obesity and metabolic syndrome. The present study aimed to investigate the changes in the plasma levels of chemerin of women with overweight and obese during a period of training on a cycle-ergometer. Materials and Methods: This study was quasi-experimental type and was performed on 22 overweight and obese women (BMI>25Kg/m2) who were within the age range of 30-45 in Zahedan. Subjects were selected targeted and using permuted block randomization was divided into two groups of subjects including training groups and control groups. The training protocol that was performed lasted for 8 weeks (3 sessions per week) by cycling on a cycle-ergometer (60-75% heart rate reserve) with a duration of 16 to 30 minutes. Blood samples were collected in two stages before and after the same conditions to measure plasma levels of chemerin. To analyze the results, t-test, ANOVA, covariance, and Kruskal-Wallis analysis were used at a significant level of α <0.05. Results: Intra-group comparisons showed that 8 weeks of aerobic exercise with ergometer bicycle in addition to a significant reduction of obesity-related factors significantly reduced plasma levels of chemerin in training groups (p=0.002). A significant difference between the changes in plasma levels of chemerin of the studied groups was observed during the inter-group comparison. Conclusion: To reduce the pre-inflammatory factor of chemerin and obesity-related factors in overweight and obese women, training on the cycle-ergometer has been considered as a preventive approach.

How to cite:
Ashtiani A R A, Galdavi R, Jafari M. Investigating endurance training with ergometer bicycle in changes the plasma levels of chemerin on overweight women. Arch. Pharm. Pract. 2021;12(1):50-4.
Ashtiani, A. R. A., Galdavi, R., & Jafari, M. (2021). Investigating endurance training with ergometer bicycle in changes the plasma levels of chemerin on overweight women. Archives Of Pharmacy Practice, 12(1),50-54.

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  1. Oqden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006;295(13):1549-55.

  2. Marinou K, Tousoulis D, Antonopoulos AS, Stefanadi E, Stefanadis C. Obesity and cardiovascular disease: from pathophysiology to risk stratification. Int J Cardiol 2010; 138(1): 3-8.

  3. Rose DP, Vona-Davis L. Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas 2010; 66(1): 33-8.

  4. Singh GK, Kogan MD, Van Dyck PC, Siahpush M. Racial/ethnic, socioeconomic, and behavioural determinants of childhood and adolescent obesity in the United States: analyzing independent and joint associations. Ann Epidemiol 2008; 18(9): 682-95.

  5. Stunkard AJ. Depression and obesity: Biological psychiatry 2003; 54(3): 330-7.

  6. Vendrell J, Broch M, Vilarrasa N, Molina A, Gómez JM, Gutiérrez C, Simón I, Soler J, Richart C. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obesity research. 2004 Jun;12(6):962-71.

  7. Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: an update. Clinical endocrinology. 2006 Apr;64(4):355-65.

  8. Gustafson B. Adipose tissue, inflammation and atherosclerosis. Journal of atherosclerosis and thrombosis. 2010;17(4):332-41.

  9. Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, Walder K, Segal D. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology. 2007 Oct 1;148(10):4687-94.

  10. Chakaroun R, Raschpichler M, Klöting N, Oberbach A, Flehmig G, Kern M, Schön MR, Shang E, Lohmann T, Dreßler M, Fasshauer M. Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity. Metabolism. 2012 May 1;61(5):706-14.

  11. Nehal Hamdy ES, Wadie Fawzy M, Nagwa AEG, Ezzat A. Role of serum chemrin level in atherosclerosis in egyptian patients with type 2 diyabetes mellitues. Journal of Applied Sciences Research 2013; 9:775-8.

  12. Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, Arner P, Eckel J. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes. 2009 Dec 1;58(12):2731-40.

  13. Saremi A, Moslehabadi MF, Parastesh M. Effects of Twelve-week strength training on serum chemerin, TNF—α and CRP level in subjects with the metabolic syndrome, Iranian Journal of  Endocrinolgy and  Metabolism 2011; 12(5): 536-43. [Persian]

  14. Watts K, Jones TW, Davis EA, Green D. Exercise training in obese children and adolescents: Current Concepts. Sports Med. 2005; 35(5):375-92.

  15. Hassink S.G, Zapalla F, Falini L, Datto G. Exercise and the obese child, Prog PEDIATR CARDIOL, 2008; 25:153–7.

  16. Chtara M, Chamari K, Chaouachi M, Chaouachi A, Koubaa D, Feki Y, Millet GP, Amri M. Effects of intra-session concurrent endurance and strength training sequence on aerobic performance and capacity. British journal of sports medicine. 2005 Aug 1;39(8):555-60.

  17. Hosseini Kakhak A, Amiri Parsa T, Haghighi A, Asgari R, Chamri M, Hedayati M.The effect of resistance training on hs- CRP and cystatin C in obese  adolescents. Bimonthly Scientific-Research Shahed University. 2009:85. [Persian]

  18. Saremi A, Shavandi N, Parastesh M, Daneshmand H. Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in overweight and obese men. Asian journal of sports medicine. 2010 Sep;1(3):151.

  19. Hajer, G.R., Van Haeften, T.W., Visseren, F., Adipose tissue dysfunction in obesity, diabetes, and vascular diseases, Eur Heart J, Vol. 29, No. 24, pp. 2959-71, 2008.

  20. Zolfaghari M, Taghian F, Hedayati M. The effects of green tea extract consumption, aerobic exercise and a combination of these on chemerin levels and insulin resistance in obese women. Iranian Journal of Endocrinology and Metabolism. 2013 Oct 10;15(3):253-61.

  21. Asgari R, Ravasi A, Gaeini A, Hedyati M, Hamedinia M. The effect of combined exercise training on indices adipokines and insulin sensitivity in overweight women. Sport and Biomotor Sciences 2011; 1(5): 25-34. [Persian]

  22. Jafari M, Mogharnasi M, Salimi Khorashad A, Effects of Endurance and Resistance Training on Plasma Levels of Chemerin and Factors Related to Obesity in Overweight and Obese Females, Armaghane-danesh, 2015, 20(4): 273-86. [Persian]

  23. Sadeghipour HR, Daryanoosh F, Salesi M. The Effect of 12 Weeks of Aerobic Interval Training on Chemerin and Vaspin Serum Concentrations and Insulin Resistance Index in Overweight Students, Journal of Zanjan university of Medical Sciences&Health Services, 2015, 23(96): 78-88. [Persian]

  24. Jackson AS, Pollock ML, Ward AN. Generalized equations for predicting body density of women. Medicine and science in sports and exercise. 1980;12(3):175-81.

  25. Jahangard T, Torkaman G, Ghoosheh B, Hedayati M, Dibaj A. The effect of short-term aerobic training on coagulation and fibrinolytic factors in sedentary healthy postmenopausal women. Maturitas. 2009 Dec 20;64(4):223-7.

  26. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical chemistry. 1972 Jun 1;18(6):499-502.

  27. Ghanbarzadeh M, Kazemi AR. The Comparison of Three Different Concurrent Training on Chemerin Plasma Levels, Insulin Resistance and Physical Performance in Elderly Women , Journal of Knowledge & Health , 2016;10(4):40-47. [Persian]

  28. Saghebjoo M, Dastigerdi S, Afzalpour ME, Hedayati M. Effects of aerobic and resistance training on plasma visfatin levels in overweight women, Koomesh, 2012, 13 (2): 225-32. [Persian]

  29. Maury E, Brichard S. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 2010; 314: 1-16.

  30. Becker M, Rabe K, Lebherz C, Zugwurst J, Göke B, Parhofer KG, Lehrke M, Broedl UC. Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet. Diabetes. 2010 Nov 1;59(11):2898-903.

  31. Ernst MC, Sinal CJ. Chemerin: at the crossroad of inflammation and obesity. Trends Endocrinol Metab 2010; 21: 660-7.

  32. Shin HY, Lee DC, Chu SH, Jeon JY, Lee MK, Im JA, Lee JW. Chemerin levels are positively correlated with abdominal visceral fat accumulation. Clinical endocrinology. 2012 Jul;77(1):47-50.

  33. Neuparth MJ, Proença JB, Santos-Silva A, Coimbra S. The positive effect of moderate walking exercise on chemerin levels in Portuguese patients with type 2 diabetes mellitus. J Investig Med 2014;62(2):350-3.

  34. Asgari R, Ravasi AA, Gaeini AA, Hedayati M, Hamedinia MR,  The effect of combined and endurance exercise training on some adipokines, GH and lipid profile  in overweight females, Journal of Sport Biosciences, 2015, 6(4): 399-413. [Persian]

  35. Yamaner F, Bayraktaroğlu T, Atmaca H, Ziyagil MA, Tamer K. Serum leptin, lipoprotein levels, and glucose homeostasis, between national wrestlers and sedentary males. Turk J Med Sci 2010; 40(3): 471-7.

  36. Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. Journal of Biological Chemistry. 2007 Sep 21;282(38):28175-88.

  37. Moradi F, Heydarzadeh A, Vosoughi-Baneh V. The effect of an endurance training program on serum levels of leptin and chemerin adipokines in inactive lean men. Feyz 2014; 18(5): 419-27.[Persian]

  38. Alfadda AA, Sallam RM, Chishti MA, Moustafa AS, Fatma S, Alomaim WS, Al-Naami MY, Bassas AF, Chrousos GP, Jo H. Differential patterns of serum concentration and adipose tissue expression of chemerin in obesity: adipose depot specificity and gender dimorphism. Molecules and cells. 2012 Jun 1;33(6):591-6.