Investigation of Interaction Between Flurbiprofen and Fatty Acid Crystals

Objectives: Interaction between flurbiprofen and saturated fatty acids keeping in view their crystalline nature has been investigated. Materials and Methods: Samples were prepared by coevaporation method. FTIR, DSC, XRD, Microscopy (Optical microscopy, Scanning electron microscopy, Atomic force microscopy) techniques were employed for study of interaction between drug and fatty acid. Results: FT-IR showed significant changes in the spectral pattern of coevaporates. Possibility of polymorphic changes and eutectic formation was completely ruled out. A better probe into interaction was obtained by microscopic techniques especially atomic force microscopy. Conclusions: XRD was unable to detect any interaction between drug and fatty acid. FT-IR study detected chemical interaction between flurbiprofen and fatty acids. Similar observations were made by DSC study. This study has clearly demonstrated interaction between flurbiprofen and fatty acid is physicochemical in nature.Objectives: Interaction between flurbiprofen and saturated fatty acids keeping in view their crystalline nature has been investigated. Materials and Methods: Samples were prepared by coevaporation method. FTIR, DSC, XRD, Microscopy (Optical microscopy, Scanning electron microscopy, Atomic force microscopy) techniques were employed for study of interaction between drug and fatty acid. Results: FT-IR showed significant changes in the spectral pattern of coevaporates. Possibility of polymorphic changes and eutectic formation was completely ruled out. A better probe into interaction was obtained by microscopic techniques especially atomic force microscopy. Conclusions: XRD was unable to detect any interaction between drug and fatty acid. FT-IR study detected chemical interaction between flurbiprofen and fatty acids. Similar observations were made by DSC study. This study has clearly demonstrated interaction between flurbiprofen and fatty acid is physicochemical in nature.