One of the most important types of chemical weapons is nerve agents. In recent years, a group of the newest, most unknown, and at the same time the most common nerve agents known as Novichok has been used in terrorist attacks. It is necessary to become more familiar with the basic and clinical chemical and pharmacologic features of this group of nerve agents for all the employees of the medical group. In this article, while reviewing the history of development and production, chemical structure, mechanism of action, toxicokinetic, and toxicology of these agents, the latest information regarding the methods of diagnosis and treatment of poisoning with these agents was also reviewed. Contrary to early information, it appears that Novichok poisoning is similar to other organophosphate agents and can be managed with prompt and appropriate treatment. Considering the existence of global threats in the field of terrorist incidents with these agents, the medical team must be familiar with these poisons to diagnose and treat the victims optimally.
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