Archive \ Volume.13 2022 Issue 3

Overview on Screening and Prevalence of Ovarian Neoplasms in Saudi Arabia

Hesham Mohammad Hamad Morcy, Nouf Dhaifallah A Almatrafi, Amal Abdulelah A Bedaiwi, Atheer Abdullah M Almijlad, Shahad Khalid A Bedaiwi, Norah Abdullah N Alsharif

One of the main health issues facing general practitioners in general and gynecologists in particular is ovarian tumors. Ovarian cancer is the second most prevalent malignancy of the female reproductive system and the fifth leading cause of cancer-related death in women. The majority of instances are discovered when the disease has already progressed even though the majority of early discovered neoplasms are benign which emphasizes the importance of early detection.                 The study aims to summarize current evidence regarding screening and the prevalence of ovarian neoplasms among Saudi women. For article selection, the PubMed database and EBSCO Information Services were used. All relevant articles relevant to our topic and other articles were used in our review. Other articles that were not related to this field were excluded. The data was extracted in a specific format that was reviewed by the group members. In the present study We found that a total of eight studies, which focused on the prevalence of ovarian cancers in various regions in Saudi Arabia. Malignant ovarian neoplasms are less frequent than benign ones. Serous cystadenoma and serous cystadenocarcinoma are the most prevalent benign and malignant ovarian neoplasms, respectively. Malignant ovarian neoplasms are more common as people get older. Most neoplastic ovarian tumors in children and adolescents are benign. The greatest rates of ASIR were found in Riyadh, Jouf, and Asir, whereas Jazan and Hail had the lowest rates.

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Morcy HMH, Almatrafi NDA, Bedaiwi AAA, Almijlad AAM, Bedaiwi SKA, Alsharif NAN. Overview on Screening and Prevalence of Ovarian Neoplasms in Saudi Arabia. Arch Pharm Pract. 2022;13(3):98-104.
Morcy, H. M. H., Almatrafi, N. D. A., Bedaiwi, A. A. A., Almijlad, A. A. M., Bedaiwi, S. K. A., & Alsharif, N. A. N. (2022). Overview on Screening and Prevalence of Ovarian Neoplasms in Saudi Arabia. Archives of Pharmacy Practice, 13(3), 98-104.

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1.        Yousif HM, Mohammed RA, Missawi HM, Elsawaf ZM, Albasri AM. Histopathological patterns of primary malignant ovarian neoplasms in different age groups in Almadinah Almunawwarah region, KSA. J Taibah Univ Med Sci. 2018;14(1):73-8. doi:10.1016/j.jtumed.2018.11.005

2.        AlDakhil L, Aljuhaimi A, AlKhattabi M, Alobaid S, Mattar RE, Alobaid A. Ovarian neoplasia in adolescence: a retrospective chart review of girls with neoplastic ovarian tumors in Saudi Arabia. J Ovarian Res. 2022;15(1):1-7. doi:10.1186/s13048-022-01033-w

3.        Karin-Kujundzic V, Covarrubias-Pinto A, Skrtic A, Vranic S, Serman L. New insight into the role of PTCH1 protein in serous ovarian carcinomas. Int J Oncol. 2022;61(6):145. doi:10.3892/ijo.2022.5435

4.        Abu-Helalah M, Azab B, Mubaidin R, Ali D, Jafar H, Alshraideh H, et al. BRCA1 and BRCA2 genes mutations among high risk breast cancer patients in Jordan. Sci Rep. 2020;10(1):17573. doi:10.1038/s41598-020-74250-2

5.        Momenimovahed Z, Ghoncheh M, Pakzad R, Hasanpour H, Salehiniya H. Incidence and mortality of uterine cancer and relationship with human development index in the world. Cukurova Med J. 2017;42(2):233-40.

6.        AlDakhil L, Aljuhaimi A, AlKhattabi M, Alobaid S, Mattar RE, Alobaid A. Ovarian neoplasia in adolescence: a retrospective chart review of girls with neoplastic ovarian tumors in Saudi Arabia. J Ovarian Res. 2022;15(1):105. doi:10.1186/s13048-022-01033-w

7.        Al-Amri IS, Kadim IT, Al-Kindi AA, Khalaf SK, Al-Harrasi AS, Al-Hashmi SA, et al. Microscopic Evaluation of Ovarian Surface Epithelium Following Treatment with Conjugated Estrogens in a Mouse Model. Asian Pac J Cancer Prev. 2022;23(6):1913-20. doi:10.31557/APJCP.2022.23.6.1913

8.        Momenimovahed Z, Tiznobaik A, Taheri S, Salehiniya H. Ovarian cancer in the world: epidemiology and risk factors. Int J Women's Health. 2019;11:287.

9.        Gkrozou F, Tsonis O, Vatopoulou A, Galaziou G, Paschopoulos M. Ovarian Teratomas in Children and Adolescents: Our Own Experience and Review of Literature. Children (Basel). 2022;9(10):1571. doi:10.3390/children9101571

10.      Breen JL, Denehy TR, Taylor RR. Pediatric ovarian malignancies. Glob Libr Women's Med. 2008. doi:10.3843/GLOWM.10251

11.      Taskinen S, Fagerholm R, Lohi J, Taskinen M. Pediatric ovarian neoplastic tumors: incidence, age at presentation, tumor markers and outcome. Acta Obstet Gynecol Scand. 2015;94(4):425-9.

12.      Arora T, Mullangi S, Lekkala MR. Ovarian Cancer. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:

13.      Saini SK, Srivastava S, Singh Y, Dixit AK, Prasad SN. Epidemiology of epithelial ovarian cancer, a single institution-based study in India. Clin Cancer Investig J. 2016;5(1):20-4.

14.      Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J, Karlan BY. Ovarian cancer. Nat Rev Dis Primers. 2016;2(1):16061. doi:10.1038/nrdp.2016.61

15.      Althubiti MA, Nour Eldein MM. Trends in the incidence and mortality of cancer in Saudi Arabia. Saudi Med J. 2018;39(12):1259-62. doi:10.15537/smj.2018.12.23348

16.      Abu-Zaid A, Nazer A, AlOmar O, Azzam A, Al-Eid HS, Elhassan TA, et al. Incidence of malignant ovarian germ cell tumors (MOGCTs) in Saudi Arabia. Hematol Oncol Stem Cell Ther. 2014;7(1):41-3.

17.      Alghamdi IG, Hussain II, Alghamdi MS, Alghamdi MM, Dohal AA, El-Sheemy MA. Incidence rate of ovarian cancer cases in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001-2008. Int J Womens Health. 2014;6:639-45. doi:10.2147/IJWH.S63636

18.      Al Jama FE, Al Ghamdi AA, Gasim T, Al Dakhiel SA, Rahman J, Rahman MS. Ovarian tumors in children and adolescents—a clinical study of 52 patients in a university hospital. J Pediatr Adolesc Gynecol. 2011;24(1):25-8.

19.      Alhuqail AJ, Alzahrani A, Almubarak H, Al-Qadheeb S, Alghofaili L, Almoghrabi N, et al. High prevalence of deleterious BRCA1 and BRCA2 germline mutations in Arab breast and ovarian cancer patients. Breast Cancer Res Treat. 2018;168(3):695-702. doi:10.1007/s10549-017-4635-4

20.      Makoha FW, Raheem MA. Gynecological cancer incidence in a hospital population in Saudi Arabia: the effect of foreign immigration over two decades. J Obstet Gynaecol Res. 2008;34(4):538-42.

21.      Mansoor I. Ovarian diseases at King Abdul-Aziz University Hospital. Saudi Med J. 2002;23(12):1551-2.

22.      Renaud EJ, Sømme S, Islam S, Cameron DB, Gates RL, Williams RF, et al. Ovarian masses in the child and adolescent: An American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee systematic review. J Pediatr Surg. 2019;54(3):369-77. doi:10.1016/j.jpedsurg.2018.08.058

23.      Akakpo PK, Derkyi-Kwarteng L, Quayson SE, Gyasi RK, Anim JT. Ovarian tumors in children and adolescents: a 10-yr histopathologic review in Korle-Bu teaching hospital, Ghana. Int J Gynecol Pathol. 2016;35(4):333-6.

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