Preparation and evaluation of a new fast dissolving oral film containing Matricaria Chamomilla extract to antisepticising Oral cavity

Many patients suffer from oral cavity infections and there is a relation between periodontal infections and systemic diseases. The extracts of medicinal plants are used directly or indirectly for the treatment of many diseases. Matricaria Chamomilla is a well-known medicinal herb used as an antimicrobial and antiviral agent, so that it can use to antisepticising oral cavity. Fast dissolving oral films (FDOF) are solid dosage forms, which the consumer can take without water or chewing and disintegrate within a few seconds in the mouth and release their ingredients. The aim of this study is the preparation and evaluation of a new FDOF containing Matricaria Chamomilla hydroalcoholic extract to antisepticising oral cavity. In this study, FDOFs containing Matricaria Chamomilla extract were made with polyvinyl alcohol and gelatin as the base polymers, and glycerin as the plasticizer by the casting method. The prepared FDOFs were evaluated for pharmaceutical properties such as surface uniformity, physical appearance (visibility, absence of air bubbles, fractures, cracks and shrinkage), flexibility, disintegration time and dissolution time. Design-Expert 11.0.3.0 (Stat-Ease, Inc., Minneapolis, USA) was used to design and optimize formulations using a random quadratic optimization model. Evaluation of the films showed that the formulation containing polyvinyl alcohol and gelatin as polymer and glycerol as plasticizer had desirable pharmaceutical properties and least disintegration and dissolution time, which ensures fast releasing of active substances. In this study a new FDOF Containing Matricaria Chamomilla extract was made. The formulated fast dissolving oral film stands as a promising dosage form for antisepticising oral cavity and Prevention of oral infections Instead of old mouthwashs.