Prescription Pattern Analysis of Nonsteroidal Anti‑ Inflammatory Drugs in the Southeastern Karnataka Population, India

Objective: To analyze the prescription pattern of Non-Steroidal Anti-Inflammatory Drugs in Bangalore Baptist Hospital, Bellary Road, Hebbal, Bangalore. Methodology:   The study method involves selection of patients based on the inclusion and exclusion Pregnant/lactating mothers were taken. The first step in the study was to design a Data collection form. The patient data collection form was used to collect all the details like Inpatients number, Patient name, Age, Sex, Date of admission, Date of discharge, Chief complaints (c/o), History of Present Illness (HOPI), Past Medication history, Laboratory data, Diagnosis and Therapeutic management. The second step in the study is prescription analysis (annexure1). It was used to study various parameters like Drug to Drug interaction, Adverse Drug Events (ADEs), Adverse Drug Reactions, Medication error and Therapeutic outcome. Result: From all the patients’ data, 245 cases were screened based on the inclusion criteria using NSAIDs and categorized into male and female. 164 (66.93%) were observed to be male and 81 (33.06%) were female. Of all the NSAIDs prescribed, Paracetamol and Aceclofenac were observed to be14.69 % and 15.10 % respectively followed by Tramadol and Diclofenac. Among all the prescriptions, oral therapy found to be most used route of administration with 47.34 % followed by parenteral therapy with 31.02 % and then topical therapy with 21.63 %. Out of 245 patients, 94 patients (38.36%) were prescribed with H2 blockers along with NSAIDs, 86 patients (35.10%) with PPI and 65 patients (26.53%) with PPI and H2 blockers. Major drug interaction observed in the patients was Fluoroquinolones+ Ondansetron in 13 patients, followed by Dexamethasone +Tramadol in 26 patients, Paracetamol+COX2 in 17 patients. Most common risk factor is the age factor with 10.61 % followed with concomitant use of anti-coagulants with 7.75 % and patients with past history of peptic ulcer. Conclusion:  A significant number of prescriptions were associated with irrational prescribing in both co-administrations of NSAIDs and GPAs and NSAIDs combination. A procedure must be created and executed for recommending and levelheaded utilization of drugs, e.g., proceeding with restorative instruction in regards to the potential dangers of NSAIDs, significance of their suitable and objective use, and need of fitting remedy composing in regards to both substance and sign.