The prevalence of atopic dermatitis (AD), a chronic skin condition, is rising globally. Worldwide, there are AD management guidelines accessible, but Saudi Arabia lacks pediatric AD-specific guidelines. This systematic review investigates the QoL and management of AD among the Saudi pediatric population. PubMed, Web of Science, Science Direct, Google Scholar, and EBSCO were systematically searched to include the relevant literature. Rayyan QRCI was used throughout this systematic approach. A total of nine studies with 2928 patients were included in this review, and 60.6% of them were males were included in this review. In this systematic review, we found that most AD patients experienced a decrease in their QoL. Bacterial colonization was relatively common among AD patients. Shared decision-making amongst the parents/caregivers, various specialties, and professionals should be the foundation of pediatric AD treatment. Emollient therapy should be advised after a careful evaluation of the severity. To create a national standard encompassing all stakeholders' thoughts and proposals, multidisciplinary collaboration is required.
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