Archive \ Volume.13 2022 Issue 3

Study of Acute and Chronic Toxicity of "Butaselmevit" on Laboratory Animals

Tetiana Martyshuk, Bogdan Gutyj, Oleg Vyshchur, Ihor Paterega, Volodymyr Kushnir, Oleksii Bigdan, Inna Bushueva, Volodymyr Parchenko, Evhenii Mykhailiuk, Oleksandr Aleksieiev, Natalia Tkachenko

The purpose of this work is to study the hepatoprotective properties of potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and infectious hepatitis models in chickens. Biochemical examination of blood and liver serum was carried out on intact broiler chickens Cobb 500 cross. All groups of chickens were kept separate in different cells in the same room for the same microclimate parameters in accordance with the established requirements. The dose-dependent effect of "Butaselmevit" on leukopoiesis, hematological profile, and functional state of the liver in laboratory animals was established.

As a result of research on the model of hepatitis in chickens caused by tetracycline, established the hepatoprotective effect of potassium compound 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate,  which is not inferior to the referent drug - Thiotriazolin®. Based on the results of the biochemical study, hepatoprotective properties of the combination of the above compound with the antibiotic Saroflox®, combination of potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate with classical antibiotic Enrofloxacin® on the model of infectious hepatitis.

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Martyshuk T, Gutyj B, Vyshchur O, Paterega I, Kushnir V, Bigdan O, et al. Study of Acute and Chronic Toxicity of "Butaselmevit" on Laboratory Animals. Arch Pharm Pract. 2022;13(3):70-5.
Martyshuk, T., Gutyj, B., Vyshchur, O., Paterega, I., Kushnir, V., Bigdan, O., Bushueva, I., Parchenko, V., Mykhailiuk, E., Aleksieiev, O., et al. (2022). Study of Acute and Chronic Toxicity of "Butaselmevit" on Laboratory Animals. Archives of Pharmacy Practice, 13(3), 70-75.

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