The effects of high-intensity interval training on fibrinolytic factors, D-dimer, and fibrinogen in men with type 2 diabetes

Background and Objective: Sudden cardiac events and thrombophilia are dominant diseases in diabetic patients. Due to the role of exercise on the homeostatic system, the effect of high intensity interval training (HIIT) on some fibrinolytic, dimer and fibrinogen factors in men with type 2 diabetes was investigated in this study. Methods: For this purpose, 24 men with type 2 diabetes who were able to participate in regular physical activity were voluntarily selected and randomly divided into two groups of HIIT (n=12) and control (n=12). These two groups were same in terms of weight and body mass index. The experimental group did exercise 8 weeks, 3 sessions per week. Changes in t-PA, TAFI, t-PA/PAI-1 complex, D-dimer and fibrinogen were analyzed before and after training using covariance statistical test at P<0.05. Results: Intergroup comparison showed that resting levels of TAFI antigen decreased (P=0.033) and t-PA/PAI-1 complex (P=0.032) increased significantly. Intergroup comparison showed that resting values of t-PA (P=0.036) increased significantly and TAFI (P=0.01), D-dimer (P=0.007) and fibrinogen (P=0.001) showed a significant decrease in the experimental group. Conclusion: It seems that the implementation of HIIT has promising effects on the fibrinolytic system of type 2 diabetic patients and may decrease the cardiovascular risks in this group of patients.