The Role of Vitamin D in Body Organ Systems: A Systematic Review

Introduction: The role of vitamin D was used to be focused on mineral homeostasis and bone reuptake. Though, discovery of the role of vitamin D in prevention form a number of diseases including breast and colon cancers, asthma, cardiovascular diseases, inflammatory bowel disease, systemic lupus erythematous, rheumatoid arthritis, type I diabetes, and infectious diseases, enhanced the importance of this vitamin. Materials and Methods: In this review article, PubMed, Scopus, Google Scholar, Medline and Embase databases were used and approximately 291 studies were assessed. Inclusion criteria of this study was using searching terms in the title and key words of the studies. 240 studies were discussed and summarized on the role of vitamin D is body organ systems. Discussion and Conclusion: Due to the extensive role of vitamin D in body organ systems, it can be considered as a treatment goal in different diseases. Moreover, considering the high prevalence of chronic diseases and vitamin D deficiency, this review article aims to discuss the role of vitamin D in body organ systems and processes such as inflammation, blood coagulation, cancer, and metastasis.