Archive \ Volume.12 2021 Issue 1

Vitamin D Effects on GH, IGF-1, Glycemic Control Indicators, and Lipid Profile in Gestational Diabetes Mellitus

Fatemeh Mohammadi , Fatemeh Bahadori , HamidReza Khalkhali , Saeid Ghavamzadeh

Gestational diabetes mellitus is an unfavorable outcome in some pregnancies, which its prevalence has increased in the world in recent years. The present study is designed and performed to evaluate the effects of oral supplementation of vitamin D on the metabolic condition of expectant women suffering from gestational diabetes. In the present double-blind randomized clinical trial study, 36 women suffering from gestational diabetes in the range of 18-40 years were randomly divided into two groups. People in the vitamin D group (n=15) got a single dose of 2000 IU/d vitamin D during six weeks of intervention, and the people in the control group (n=15) similarly got placebo. Blood specimens of the persons were taken as fasting once at the research beginning and once at the termination of the sixth week of intermediation.

In total, 30 participants were entered into the final analysis. In the vitamin D group, it was found a significant decrease in FPG (-0.4±10 vs -14.8±14.4, p=0.004), insulin (-0.2±1 vs -0.7±1.2, p=0.03) and HOMA-IR (-0.4±0.3 vs 0.1±0.4, p=0.001) and a significant enhancement in HOMA_B (184.5±120 vs -4.2±105, p<0.001) and QUICKI (0.009±0.008 vs -0.003±0.008, p<0.001) in comparison to the control group. Vitamin D3 supplementation had no significant impact on serum contents of total cholesterol, triglyceride, LDL, HDL, IGF-1, and growth hormone levels. Supplementation with 2000 IU vitamin D3 for six weeks has positive effects on glycemic condition control in expectant women suffering from GDM but does not affect the lipid profile, growth hormone, and IGF-1 levels, in them.

How to cite:
Mohammadi F, Bahadori F, Khalkhali H, Ghavamzadeh S. Vitamin D Effects on GH, IGF-1, Glycemic Control Indicators, and Lipid Profile in Gestational Diabetes Mellitus. Arch. Pharm. Pract. 2021;12(1):118-25.
Mohammadi, F., Bahadori, F., Khalkhali, H., & Ghavamzadeh, S. (2021). Vitamin D Effects on GH, IGF-1, Glycemic Control Indicators, and Lipid Profile in Gestational Diabetes Mellitus. Archives Of Pharmacy Practice, 12(1),118-125.

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1.        Rani PR, Begum J. Screening and diagnosis of gestational diabetes mellitus, where do we stand. J Clin Diagn Res. 2016;10(4):QE01.

2.        Asemi Z, Karamali M, Esmaillzadeh A. Favorable effects of vitamin D supplementation on pregnancy outcomes in gestational diabetes: a double-blind randomized controlled clinical trial. Horm Metab Res. 2015;47(08):565-70.

3.        Asemi Z, Karamali M, Jamilian M, Foroozanfard F, Bahmani F, Heidarzadeh Z, et al. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(1):222-9.

4.        Almasi S, Salehiniya H. The prevalence of gestational diabetes mellitus in Iran (1993-2013): a systematic review. J Isfahan Med Sch. 2014;32(299):1396-412.

5.        Harreiter J, Dovjak G, Kautzky-Willer A. Gestational diabetes mellitus and cardiovascular risk after pregnancy. Women’s Health. 2014;10(1):91-108.

6.        Poel Y, Hummel P, Lips P, Stam F, Van Der Ploeg T, Simsek S. Vitamin D and gestational diabetes: a systematic review and meta-analysis. Eur J Intern Med. 2012;23(5):465-9.

7.        Burris HH, Rifas-Shiman SL, Kleinman K, Litonjua AA, Huh SY, Rich-Edwards JW, et al. Vitamin D deficiency in pregnancy and gestational diabetes mellitus. Am J Obstet Gynecol. 2012;207(3):182. e1-8.

8.        Akbari M, Moosazadeh M, Lankarani KB, Tabrizi R, Samimi M, Karamali M, et al. The Effects of Vitamin D Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2017;49(09):647-53.

9.        Ji LL, Tong L, Peng JB, Jin XH, Wei D, Xu BK, et al. Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress. Mol Med Report. 2014;9(4):1165-70.

10.      Asemi Z, Hashemi T, Karamali M, Samimi M, Esmaillzadeh A. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. Am J Clin Nutr. 2013;98(6):1425-32.

11.      Després JP. The insulin resistance—dyslipidemic syndrome of visceral obesity: effect on patients' risk. Obes Res. 1998;6(S1):8S-17S.

12.      Steiner G. Hyperinsulinaemia and hypertriglyceridaemia. J Intern Med Suppl. 1994;736:23-6.

13.      Pleskačová A, Bartáková V, Pácal L, Kuricová K, Bělobrádková J, Tomandl J, et al. Vitamin D status in women with gestational diabetes mellitus during pregnancy and postpartum. Biomed Res Int. 2015;2015.

14.      Wagner CL, Taylor SN, Dawodu A, Johnson DD, Hollis BW. Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus. Nutrients. 2012;4(3):208-30.

15.      Meinilä J, Koivusalo SB, Valkama A, Rönö K, Erkkola M, Kautiainen H, et al. Nutrient intake of pregnant women at high risk of gestational diabetes. Food Nutr Res. 2015;59(1):26676.

16.      Verburg PE, Tucker G, Scheil W, Erwich JJH, Dekker GA, Roberts CT. Seasonality of gestational diabetes mellitus: a South Australian population study. BMJ Open Diabetes Res Care. 2016;4(1):e000286.

17.      Nielsen JH, Galsgaard ED, Møldrup A, Friedrichsen BN, Billestrup N, Hansen JA, et al. Regulation of beta-cell mass by hormones and growth factors. Diabetes. 2001;50(suppl 1):S25.

18.      Møller N, Jørgensen JOL. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009;30(2):152-77.

19.      Jacob R, Barrett E, Plewe G, Fagin KD, Sherwin RS. Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. Comparison with insulin. J Clin Invest. 1989;83(5):1717-23.

20.      Panahi M, Alli Z, Cheng X, Belbaraka L, Belgoudi J, Sardana R, et al. Recombinant protein expression plasmids optimized for industrial E. coli fermentation and plant systems produce biologically active human insulin-like growth factor-1 in transgenic rice and tobacco plants. Transgenic Res. 2004;13(3):245-59.

21.      Mazziotti G, Chiavistelli S, Giustina A. Pituitary Diseases and Bone. Endocrinol Metab Clin. 2015;44(1):171-80.

22.      Yazdchi R, Gargari BP, Asghari-Jafarabadi M, Sahhaf F. Effects of vitamin D supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: a randomized, double-blinded, placebo-controlled clinical trial. Nutr Res Pract. 2016;10(3):328-35.

23.      Association AD. Gestational diabetes mellitus. Diabetes Care. 2004;27(suppl 1):s88-s90.

24.      Gupta P, Narang M, Banerjee B, Basu S. Oxidative stress in term small for gestational age neonates born to undernourished mothers: a case control study. BMC Pediatr. 2004;4(1):14.

25.      International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger B, Gabbe S, Persson B, Buchanan T, Catalano P, Damm P, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676-82.

26.      Association AD. Standards of medical care in diabetes—2014. Diabetes Care. 2014;37(Supplement 1):S14-80.

27.      Garrison A. Screening, diagnosis, and management of gestational diabetes mellitus. Am Fam Physician. 2015;91(7):460-7.

28.      Perez-Mendez O, Pacheco HG, Martinez-Sanchez C, Franco M. HDL-cholesterol in coronary artery disease risk: function or structure? Clin Chim Acta. 2014;429:111-22.

29.      Garrison EA, Jagasia S. Inpatient management of women with gestational and pregestational diabetes in pregnancy. Curr Diab Rep. 2014;14(2):457.

30.      Yap C, Cheung NW, Gunton JE, Athayde N, Munns CF, Duke A, et al. Vitamin D supplementation and the effects on glucose metabolism during pregnancy: a randomized controlled trial. Diabetes Care. 2014;37(7):1837-44.

31.      Zhang C, Qiu C, Hu FB, David RM, Van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One. 2008;3(11):e3753.

32.      Pérez-López FR, Chedraui P, Fernández-Alonso AM. Vitamin D and aging: beyond calcium and bone metabolism. Maturitas. 2011;69(1):27-36.

33.      Ponsonby A-L, Lucas RM, Lewis S, Halliday J. Vitamin D status during pregnancy and aspects of offspring health. Nutrients. 2010;2(3):389-407.

34.      Wacker M, Holick M. Vitamin D—effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013;5(1):111-48.

35.      Fernández‐Alonso AM, Dionis‐Sánchez EC, Chedraui P, González‐Salmerón MD, Pérez‐López FR, D SV, et al. First‐trimester maternal serum 25‐hydroxyvitamin D3 status and pregnancy outcome. Int J Gynecol Obstet. 2012;116(1):6-9.

36.      Zhang Q, Cheng Y, He M, Li T, Ma Z, Cheng H. Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: a randomized controlled trial. Exp Ther Med. 2016;12(3):1889-95.

37.      Wolden-Kirk H, Overbergh L, Christesen HT, Brusgaard K, Mathieu C. Vitamin D and diabetes: its importance for beta cell and immune function. Mol Cell Endocrinol. 2011;347(1-2):106-20.

38.      Hyppönen E, Berry D, Cortina-Borja M, Power C. 25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort. PLoS One. 2010;5(5):e10801.

39.      Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011;57(1):63-9.

40.      Ojo O, Weldon SM, Thompson T, Vargo EJ. The effect of Vitamin D supplementation on glycaemic control in women with Gestational Diabetes Mellitus: A systematic review and meta-analysis of randomised controlled trials. Int J Environ Res Public Health. 2019;16(10):1716.

41.      Asemi Z, Karamali M, Esmaillzadeh A. Effects of calcium–vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial. Diabetologia. 2014;57(9):1798-806.

42.      Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among US adults. Diabetes Care. 2005;28(5):1228-30.

43.      Chaudhuri JR, Mridula KR, Anamika A, Boddu DB, Misra PK, Lingaiah A, et al. Deficiency of 25-hydroxyvitamin d and dyslipidemia in Indian subjects. J Lipids. 2013;2013.

44.      Qin XF, Zhao LS, Chen WR, Wang H. Effects of vitamin D on plasma lipid profiles in statin-treated patients with hypercholesterolemia: A randomized placebo-controlled trial. Clin Nutr. 2015;34(2):201-6.

45.      Steger FL. Associations between vitamin D status and blood lipid parameters in healthy, older adults. 2013.

46.      Kassi E, Adamopoulos C, Basdra EK, Papavassiliou AG. Role of vitamin D in atherosclerosis. Circulation. 2013;128(23):2517-31.

47.      Harbison MD, Gertner JM. Permissive action of growth hormone on the renal response to dietary phosphorus deprivation. J Clin Endocrinol Metab. 1990;70(4):1035-40.

48.      Ameri P, Giusti A, Boschetti M, Bovio M, Teti C, Leoncini G, et al. Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency. Eur J Endocrinol. 2013;169(6):767-72.

49.      Ameri P, Giusti A, Boschetti M, Murialdo G, Minuto F, Ferone D. Interactions between vitamin D and IGF‐I: from physiology to clinical practice. Clin Endocrinol (Oxf). 2013;79(4):457-63.

50.      Clemmons DR. Involvement of insulin-like growth factor-I in the control of glucose homeostasis. Curr Opin Pharmacol. 2006;6(6):620-5.