Arterial hypertension is one of the most common chronic diseases. Regular blood pressure control to reach the target level is considered as the main way to reduce the risk of developing cardiovascular complications. Therapeutic classes, which are used as first-line drugs include calcium channel blockers (CCB), β-blockers, diuretics, angiotensin II receptor blockers (ARBs), and angiotensin-converting enzyme (ACE) inhibitors. The aim of the study is to analyze the intra-group preferences of the patients of the Far Eastern Federal District (FSD) when purchasing the five main classes of antihypertensive drugs. Materials and methods: DDD-analysis (162 pharmacy organizations), marketing analysis (share of realization), and statistical analysis (criteria of Kruskal-Wallis, and Spearman) were carried out. Results: The most acquired antihypertensive drugs in the therapeutic class of β-blockers is bisoprolol; among CCB is amlodipine; among the group of diuretics is indapamide; in the ARBs class are losartan and valsartan; and among the ACE inhibitors are enalapril and lisinopril. There are no statistically reliable differences in the structure of the purchase of drugs between the subjects of the FSD. Conclusion: The obtained data prove the unity of the approaches in carrying out drug therapy of arterial hypertension in ten subjects of FSD, and accordingly the full introduction of the guideline into functioning regional health systems. Scientific contribution: Research planning, DDD analysis, marketing analysis, statistical analysis, interpretation and generalization of the obtained data were carried out by the authors. Field of application: The results of this study can be used to assess the compliance of medical care with the current standards, as well as to plan the procurement of antihypertensive drugs for state and municipal needs to optimize the assortment matrix in pharmacy organizations. Future research may conduct a comparative analysis of the structure of antihypertensive drugs acquisition by patients of densely populated western and central regions with the subjects of the FSD.